The effect of surgically induced weight reduction on the serum levels of the cytokines: interleukin-3 and tumor necrosis factor

Morbid obesity and malnutrition have both been demonstrated to have deleterious effects on the immune function. Cytokines are immunomodulatory peptides that have profound effects on immune function. To the authors' knowledge, the effect of surgically induced weight reduction on the cytokine lev...

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Bibliographic Details
Published in:Obesity surgery 1999-06, Vol.9 (3), p.229-234
Main Authors: Kyzer, S, Binyamini, J, Chaimoff, C, Fishman, P
Format: Article
Language:English
Subjects:
Case-Control Studies
Cytokines
Female
Gastrointestinal surgery
Gastroplasty
Humans
Immunology
Interleukin-3 - blood
Male
Obesity
Obesity, Morbid - blood
Obesity, Morbid - surgery
Surgical outcomes
Tumor Necrosis Factor-alpha - analysis
Weight control
Weight Loss
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Summary:Morbid obesity and malnutrition have both been demonstrated to have deleterious effects on the immune function. Cytokines are immunomodulatory peptides that have profound effects on immune function. To the authors' knowledge, the effect of surgically induced weight reduction on the cytokine levels has yet not been studied. In the present study, the authors determined the effect of surgically induced weight reduction on the levels of the cytokines interleukin-3 (IL-3) and tumor necrosis factor-alpha (TNF-alpha). 14 patients undergoing silicone ring vertical gastroplasty were included in the study (mean BMI 48.85 kg/m2; range 38.1-52.0 kg/m2). Determination of the IL-3 and TNF-alpha levels was performed preoperatively and 14 days and 6 months postoperatively, when all patients had lost 25% to 30% of their preoperative weight. The IL-3 values before the procedure, and 14 days and 6 months after, were as follows: 9.69 +/- 1.82, 9.36 +/- 1.28, and 8.42 +/- 1.26 pg/mL, respectively (P < 0.05 preoperative versus 6 months postoperative level). The preoperative TNF-alpha levels showed a wide distribution. For this reason, the patients were divided into two groups: Group A with preoperative values >10 pg/mL and Group B with values
ISSN:0960-8923
1708-0428
DOI:10.1381/096089299765553089