Soluble adhesion molecules in serum and cyst fluid from patients with cystic tumours of the ovary

The potential of the soluble forms of the adhesion molecules ICAM-1 (sICAM-1), CD44std (sCD44std) and E-cadherin (sE-cadherin) was tested for the diagnosis of benign and malignant cystic epithelial tumours of the ovary. Concentrations of sICAM-1, sCD44 std and sE-cadherin were measured by enzyme-lin...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1998-10, Vol.13 (10), p.2831-2835
Main Authors: Daraï, E, Bringuier, A F, Walker-Combrouze, F, Feldmann, G, Madelenat, P, Scoazec, J Y
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - blood
Biomarkers, Tumor - metabolism
Cadherins - blood
Cadherins - metabolism
Cell Adhesion Molecules - blood
Cell Adhesion Molecules - metabolism
Cyst Fluid - metabolism
Cystadenocarcinoma - blood
Cystadenocarcinoma - metabolism
Cystadenoma - blood
Cystadenoma - metabolism
Dermoid Cyst - blood
Dermoid Cyst - metabolism
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Hyaluronan Receptors - blood
Hyaluronan Receptors - metabolism
Intercellular Adhesion Molecule-1 - blood
Intercellular Adhesion Molecule-1 - metabolism
Medical sciences
Middle Aged
Ovarian Cysts - blood
Ovarian Cysts - metabolism
Ovarian Neoplasms - blood
Ovarian Neoplasms - diagnosis
Ovarian Neoplasms - metabolism
Tumors
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Summary:The potential of the soluble forms of the adhesion molecules ICAM-1 (sICAM-1), CD44std (sCD44std) and E-cadherin (sE-cadherin) was tested for the diagnosis of benign and malignant cystic epithelial tumours of the ovary. Concentrations of sICAM-1, sCD44 std and sE-cadherin were measured by enzyme-linked immunosorbent assay (ELISA) in the serum and cyst fluid obtained from 23 patients with luteal cysts, 29 with cystadenomas, nine with dermoid cysts, five with borderline tumours and 11 with carcinomas. Serum concentrations of sICAM-1, but not of sCD44std and sE-cadherin, were constantly elevated compared with normal controls. Cyst fluid concentrations of sICAM-1, sCD44std and sE-cadherin were elevated in borderline and malignant tumours compared with cystadenomas (P = 0.034, 0.006 and 0.001, respectively). In conclusion, our results suggest that serum concentrations of adhesion molecules have no diagnostic value in ovarian tumours, whereas cyst fluid concentrations may facilitate distinction between benign lesions and borderline or malignant tumours.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/13.10.2831