Neocrotocembranal from Croton oblongifolius

A new cembranoid diterpene, neocrotocembranal (3), was isolated from the stem bark of Croton oblongifolius. Its structure was established on the basis of spectroscopic analysis. This compound inhibited platelet aggregation induced by thrombin, with an IC50 value of 47.21 microg/mL, and exhibited cyt...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1163-1164
Main Authors: Roengsumran, S, Singtothong, P, Pudhom, K, Ngamrochanavanich, N, Petsom, A, Chaichantipyuth, C
Format: Article
Language:English
Subjects:
Animals
antineoplastic agents
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
bark
Biological and medical sciences
cell lines
chemical constituents of plants
chemical structure
Croton
cytotoxic compounds
Diterpenes - isolation & purification
Diterpenes - pharmacology
diterpenoids
Drug Screening Assays, Antitumor
Euphorbiaceae - chemistry
General pharmacology
In Vitro Techniques
inhibition
Leukemia P388 - drug therapy
Magnetic Resonance Spectroscopy
Medical sciences
medicinal plants
p-388 cell lines
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Epidermis - chemistry
Plant Stems - chemistry
platelet aggregation
Platelet Aggregation - drug effects
Rabbits
spectral analysis
Spectrophotometry, Ultraviolet
stems
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Summary:A new cembranoid diterpene, neocrotocembranal (3), was isolated from the stem bark of Croton oblongifolius. Its structure was established on the basis of spectroscopic analysis. This compound inhibited platelet aggregation induced by thrombin, with an IC50 value of 47.21 microg/mL, and exhibited cytotoxicity against P-388 cells in vitro, with an IC(50) value of 6.48 microg/mL.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9900268