Left Ventricular Mass, Stroke Volume, and Ouabain-Like Factor in Essential Hypertension

Many patients with essential hypertension (EH) exhibit increased left ventricular mass. Similarly, elevated circulating levels of an endogenous ouabainlike factor (OLF) have been described in some but not all patients with EH. Moreover, ouabain has a hypertrophic influence on isolated cardiac myocyt...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-09, Vol.34 (3), p.450-456
Main Authors: Manunta, Paolo, Stella, Paola, Rivera, Rodolfo, Ciurlino, Daniele, Cusi, Daniele, Ferrandi, Mara, Hamlyn, John M, Bianchi, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Humans
Hypertension - metabolism
Hypertension - physiopathology
Hypertrophy, Left Ventricular
Male
Medical sciences
Middle Aged
Ouabain - metabolism
Regression Analysis
Stroke Volume
Ventricular Function
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Many patients with essential hypertension (EH) exhibit increased left ventricular mass. Similarly, elevated circulating levels of an endogenous ouabainlike factor (OLF) have been described in some but not all patients with EH. Moreover, ouabain has a hypertrophic influence on isolated cardiac myocytes. Accordingly, we investigated relationships among plasma OLF, left ventricular mass, and cardiac function in patients with EH. Plasma OLF was determined in 110 normotensive subjects and 128 patients with EH. Echocardiographic parameters and humoral determinants were measured in EH. Plasma OLF levels were increased (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.34.3.450