Semisynthesis and Cytotoxicity of Styryl-Lactone Derivatives

The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cyto...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1106-1109
Main Authors: Bermejo, Almudena, Léonce, Stéphane, Cabedo, Nuria, Andreu, Inmaculada, Caignard, Daniel H, Atassi, Ghanem, Cortes, Diego
Format: Article
Language:English
Subjects:
altholactone
Animals
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemical synthesis
Antineoplastic Agents, Phytogenic - pharmacology
biochemical pathways
Biological and medical sciences
cell cycle
cell lines
chemical constituents of plants
chemical reactions
chemical structure
cytotoxic compounds
derivatives
Drug Screening Assays, Antitumor
General aspects
goniofufurone
Goniothalamus
goniothalamus arvensis
l-1210 cell lines
lactones
Lactones - chemical synthesis
Lactones - pharmacology
Leukemia L1210 - drug therapy
Medical sciences
medicinal plants
Mice
Molecular Conformation
New Guinea
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
precursors
regulation
spectral analysis
stearic acid
structure-activity relationships
synthesis
Tumor Cells, Cultured
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Summary:The cytotoxicity and the cell-cycle action of altholactone (1), goniofufurone (2), and eight altholactone derivatives (5−12), were determined in vitro on L-1210 cells. Semisyntheses and structure−activity relationships of these compounds are described. The results of this study suggest that the cytotoxicity of altholactone (1), 11-nitro-altholactone (8), and 7-chloro-6,7-dihydroaltholactone (10) is due to the accumulation of the cells in the G2 + M phase of the cell cycle.
ISSN:0163-3864
1520-6025
DOI:10.1021/np990089q