Antinociceptive Activity of Niga-ichigoside F1 from Rubus imperialis

This work describes the antinociceptive effect of a triterpene glycoside, niga-ichigoside F1 (1), obtained from an EtOAc extract of the aerial parts of Rubus imperialis. When evaluated against an HOAc-induced writhing model, it exhibited an ID50 value of 3.1 mg/kg (ip). Moreover, in a formalin-induc...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1145-1146
Main Authors: Niero, R, Cechinel Filho, V, Souza, M. M, Montanari, J. L, Yunes, R. A, Delle Monache, F
Format: Article
Language:English
Subjects:
Acetic Acid
analgesics
Analgesics - chemistry
Analgesics - isolation & purification
Analgesics - pharmacology
Animals
Biological and medical sciences
Brazil
chemical constituents of plants
chemical structure
Formaldehyde
General pharmacology
glycosides
Magnetic Resonance Spectroscopy
Male
Medical sciences
medicinal plants
Mice
Pain Measurement - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rubus
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
spectral analysis
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
triterpenoids
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Summary:This work describes the antinociceptive effect of a triterpene glycoside, niga-ichigoside F1 (1), obtained from an EtOAc extract of the aerial parts of Rubus imperialis. When evaluated against an HOAc-induced writhing model, it exhibited an ID50 value of 3.1 mg/kg (ip). Moreover, in a formalin-induced pain model, both phases of pain were inhibited by compound 1, with ID50 values of 2.6 (first phase) and 2.7 (second phase) mg/kg, (ip), respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9804177