Essential fatty acid deficiencies in patients with chronic liver disease are not reversed by short-term intravenous lipid supplementation

The purpose of this study was to determine the plasma triglyceride and phospholipid fatty acid (FA) composition of severely malnourished patients with chronic liver disease and to examine the effects of parenteral nutrition with a total nutrient admixture (TNA) on these profiles. Nine consecutive pa...

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Bibliographic Details
Published in:Digestive diseases and sciences 1999-07, Vol.44 (7), p.1342-1348
Main Authors: DUERKSEN, D. R, NEHRA, V, PALOMBO, J. D, AHMAD, A, BISTRIAN, B. R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Chronic Disease
Digestive system
Fat Emulsions, Intravenous - administration & dosage
Fatty Acids, Essential - administration & dosage
Fatty Acids, Essential - blood
Fatty Acids, Essential - deficiency
Female
Gastrointestinal Neoplasms - physiopathology
Gastrointestinal Neoplasms - therapy
Graft Rejection - physiopathology
Graft Rejection - therapy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Liver Diseases - physiopathology
Liver Diseases - therapy
Liver Failure - physiopathology
Liver Failure - therapy
Liver Transplantation - physiology
Male
Medical sciences
Middle Aged
Parenteral Nutrition, Total
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phospholipids - blood
Postoperative Complications - physiopathology
Postoperative Complications - therapy
Protein-Energy Malnutrition - physiopathology
Protein-Energy Malnutrition - therapy
Treatment Outcome
Triglycerides - blood
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Summary:The purpose of this study was to determine the plasma triglyceride and phospholipid fatty acid (FA) composition of severely malnourished patients with chronic liver disease and to examine the effects of parenteral nutrition with a total nutrient admixture (TNA) on these profiles. Nine consecutive patients with end-stage chronic liver disease were compared with 35 patients admitted for elective surgery of upper gastrointestinal malignancy. Baseline laboratory values and the FA profiles of the plasma triglyceride and phospholipids were analyzed. FA profiles were also performed after infusion of a TNA including 33+/-7 g of lipid/24 hr for 7.9+/-4 days in the patients with chronic liver disease. Compared with control patients, the plasma phospholipid fatty acid analysis results (relative mole percentage) of patients with chronic liver disease were significantly lower in the two essential FA, linoleic acid (15.4+/-3.4% vs. 20.8+/-2.9%, P
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1026683214681