Coxsackievirus B4 myocarditis in an orangutan

A 37-year-old female orangutan died at the zoological garden. Autopsy examination demonstrated severe coxsackievirus B4 myocarditis immunohistochemically as a cause of the death. Apoptosis of the cardiac muscle cells was observed using the TdT-mediated dUTP-biotin nick endo labeling method and was c...

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Bibliographic Details
Published in:Veterinary pathology 1999-09, Vol.36 (5), p.452-456
Main Authors: Miyagi, J, Tsuhako, K, Kinjo, T, Iwamasa, T, Kamada, Y, Kinju, T, Koyanagi, Y
Format: Article
Language:English
Subjects:
Animals
Animals, Zoo
Antibodies, Monoclonal
apoptosis
Blotting, Southern - veterinary
case studies
Coxsackievirus Infections - pathology
Coxsackievirus Infections - veterinary
disease transmission
DNA Primers - chemistry
DNA, Viral - chemistry
Electrophoresis, Agar Gel - veterinary
Electrophoresis, Polyacrylamide Gel - veterinary
Enterovirus
Enterovirus B, Human - pathogenicity
Female
Human herpesvirus 4
humans
Immunohistochemistry
In Situ Nick-End Labeling - veterinary
infection
liver
lungs
lymph nodes
myocarditis
Myocarditis - pathology
Myocarditis - veterinary
Myocardium - pathology
necropsy
Polymerase Chain Reaction - veterinary
Pongo pygmaeus
Sequence Analysis, DNA
zoo animals
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Summary:A 37-year-old female orangutan died at the zoological garden. Autopsy examination demonstrated severe coxsackievirus B4 myocarditis immunohistochemically as a cause of the death. Apoptosis of the cardiac muscle cells was observed using the TdT-mediated dUTP-biotin nick endo labeling method and was considered to play a role in the myocarditis. Congestion of the liver and both lungs due to cardiac failure was also observed. Coxsackievirus infection is found frequently in the Okinawan human population. The present orangutan's infection might have come from visitors who were allowed to go near the orangutan. Malignant tumors, severe suppurative infections, and intestinal parasite infections were not observed. Epstein-Barr virus DNA was detected in lymph nodes, but there was no Burkitt's lymphoma.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.36-5-452