HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar

The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A,...

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Bibliographic Details
Published in:Parasitology research (1987) 1999-10, Vol.85 (10), p.833-836
Main Authors: VALDEZ, E, DEL CARMEN MARTINEZ, M, MELENDRO, E. I, RAMIRO, M, KRETSCHMER, R, MUNOZ, O, XIMENEZ, C, GOMEZ, A, CEDILLO, R, ARELLANO, J, PEREZ, M. E, RAMOS, F, MORAN, P, GONZALEZ, E, VALENZUELA, O
Format: Article
Language:English
Subjects:
Amibiasis
Animals
Antibodies, Protozoan - analysis
Biological and medical sciences
Case-Control Studies
Disease Susceptibility
DNA, Protozoan - analysis
Dysentery, Amebic - blood
Dysentery, Amebic - parasitology
Entamoeba histolytica - genetics
Entamoeba histolytica - immunology
Entamoeba histolytica - pathogenicity
Feces - parasitology
Follow-Up Studies
HLA-A Antigens - analysis
HLA-B Antigens - analysis
HLA-DR Antigens - analysis
Human protozoal diseases
Humans
Infectious diseases
Lymphocytes - immunology
Medical sciences
Parasitic diseases
Polymerase Chain Reaction
Protozoal diseases
Tropical medicine
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Summary:The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found.
ISSN:0932-0113
1432-1955
DOI:10.1007/s004360050641