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HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar
The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A,...
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| Published in: | Parasitology research (1987) 1999-10, Vol.85 (10), p.833-836 |
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| Main Authors: | , , , , , , , , , , , , , , |
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| container_end_page | 836 |
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| container_title | Parasitology research (1987) |
| container_volume | 85 |
| creator | VALDEZ, E DEL CARMEN MARTINEZ, M MELENDRO, E. I RAMIRO, M KRETSCHMER, R MUNOZ, O XIMENEZ, C GOMEZ, A CEDILLO, R ARELLANO, J PEREZ, M. E RAMOS, F MORAN, P GONZALEZ, E VALENZUELA, O |
| description | The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found. |
| doi_str_mv | 10.1007/s004360050641 |
| format | article |
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I ; RAMIRO, M ; KRETSCHMER, R ; MUNOZ, O ; XIMENEZ, C ; GOMEZ, A ; CEDILLO, R ; ARELLANO, J ; PEREZ, M. E ; RAMOS, F ; MORAN, P ; GONZALEZ, E ; VALENZUELA, O</creator><creatorcontrib>VALDEZ, E ; DEL CARMEN MARTINEZ, M ; MELENDRO, E. I ; RAMIRO, M ; KRETSCHMER, R ; MUNOZ, O ; XIMENEZ, C ; GOMEZ, A ; CEDILLO, R ; ARELLANO, J ; PEREZ, M. E ; RAMOS, F ; MORAN, P ; GONZALEZ, E ; VALENZUELA, O</creatorcontrib><description>The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s004360050641</identifier><identifier>PMID: 10494810</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Amibiasis ; Animals ; Antibodies, Protozoan - analysis ; Biological and medical sciences ; Case-Control Studies ; Disease Susceptibility ; DNA, Protozoan - analysis ; Dysentery, Amebic - blood ; Dysentery, Amebic - parasitology ; Entamoeba histolytica - genetics ; Entamoeba histolytica - immunology ; Entamoeba histolytica - pathogenicity ; Feces - parasitology ; Follow-Up Studies ; HLA-A Antigens - analysis ; HLA-B Antigens - analysis ; HLA-DR Antigens - analysis ; Human protozoal diseases ; Humans ; Infectious diseases ; Lymphocytes - immunology ; Medical sciences ; Parasitic diseases ; Polymerase Chain Reaction ; Protozoal diseases ; Tropical medicine</subject><ispartof>Parasitology research (1987), 1999-10, Vol.85 (10), p.833-836</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c318t-b298b358584afa2ffa74e6a65913b915c7b3d6aad980147568e11f119a1ca9823</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1932236$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10494810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VALDEZ, E</creatorcontrib><creatorcontrib>DEL CARMEN MARTINEZ, M</creatorcontrib><creatorcontrib>MELENDRO, E. I</creatorcontrib><creatorcontrib>RAMIRO, M</creatorcontrib><creatorcontrib>KRETSCHMER, R</creatorcontrib><creatorcontrib>MUNOZ, O</creatorcontrib><creatorcontrib>XIMENEZ, C</creatorcontrib><creatorcontrib>GOMEZ, A</creatorcontrib><creatorcontrib>CEDILLO, R</creatorcontrib><creatorcontrib>ARELLANO, J</creatorcontrib><creatorcontrib>PEREZ, M. E</creatorcontrib><creatorcontrib>RAMOS, F</creatorcontrib><creatorcontrib>MORAN, P</creatorcontrib><creatorcontrib>GONZALEZ, E</creatorcontrib><creatorcontrib>VALENZUELA, O</creatorcontrib><title>HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><description>The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. 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| ispartof | Parasitology research (1987), 1999-10, Vol.85 (10), p.833-836 |
| issn | 0932-0113 1432-1955 |
| language | eng |
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| source | Springer Nature |
| subjects | Amibiasis Animals Antibodies, Protozoan - analysis Biological and medical sciences Case-Control Studies Disease Susceptibility DNA, Protozoan - analysis Dysentery, Amebic - blood Dysentery, Amebic - parasitology Entamoeba histolytica - genetics Entamoeba histolytica - immunology Entamoeba histolytica - pathogenicity Feces - parasitology Follow-Up Studies HLA-A Antigens - analysis HLA-B Antigens - analysis HLA-DR Antigens - analysis Human protozoal diseases Humans Infectious diseases Lymphocytes - immunology Medical sciences Parasitic diseases Polymerase Chain Reaction Protozoal diseases Tropical medicine |
| title | HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar |
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