Micromechanical Devices for Intravascular Drug Delivery

Microfabrication technology, more commonly applied to the manufacture of integrated circuits, can be used to build devices useful for mechanical delivery of drugs and genes. Microprobes fabricated using silicon micromachining have been used to deliver DNA into cells as an alternative to bombardment...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1998-11, Vol.87 (11), p.1387-1394
Main Authors: Reed, Michael L., Wu, Clarence, Kneller, James, Watkins, Simon, Vorp, David A., Nadeem, Ahmed, Weiss, Lee E., Rebello, Keith, Mescher, Mark, Conrad Smith, A.J., Rosenblum, Warren, Feldman, Marc D.
Format: Article
Language:English
Subjects:
Animals
Arterial Occlusive Diseases - therapy
Arteries
Biological and medical sciences
Coronary Disease - therapy
DNA - administration & dosage
Drug Implants
General pharmacology
Genetic Therapy
Humans
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Stents
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Summary:Microfabrication technology, more commonly applied to the manufacture of integrated circuits, can be used to build devices useful for mechanical delivery of drugs and genes. Microprobes fabricated using silicon micromachining have been used to deliver DNA into cells as an alternative to bombardment and microinjection. This idea can be extended to intravascular stents with integrated microprobes capable of piercing compressed plaque and delivering anti-restenosis therapies into coronary arteries. Preliminary experiments using filleted rabbit arteries have demonstrated transection of the internal elastic lamina. New nonplanar microfabrication technologies are necessary for creating practical devices with cylindrical symmetry; a promising possibility is to use microfabricated structures of anodic metal oxides.
ISSN:0022-3549
1520-6017
DOI:10.1021/js980085q