Prognostic value of a doppler index combining systolic and diastolic performance in idiopathic-dilated cardiomyopathy

This study sought to investigate, in patients with idiopathic-dilated cardiomyopathy, the clinical and prognostic value of a Doppler-derived index of myocardial function that combines systolic and diastolic time intervals of the left heart cycle. The Doppler index was measured in 75 patients (aged 6...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 1998-11, Vol.82 (9), p.1071-1076
Main Authors: Dujardin, Karl S., Tei, Chuwa, Yeo, Tiong Cheng, Hodge, David O., Rossi, Andrea, Seward, James B.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathy, Dilated - complications
Cardiomyopathy, Dilated - diagnostic imaging
Cardiomyopathy, Dilated - physiopathology
Cardiovascular disease
Diastole
Doppler effect
Echocardiography, Doppler
Female
Heart
Humans
Male
Medical research
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Predictive Value of Tests
Prognosis
Retrospective Studies
Survival Analysis
Systole
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - diagnostic imaging
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study sought to investigate, in patients with idiopathic-dilated cardiomyopathy, the clinical and prognostic value of a Doppler-derived index of myocardial function that combines systolic and diastolic time intervals of the left heart cycle. The Doppler index was measured in 75 patients (aged 61 ± 13 years; 45 men and 30 women) in sinus rhythm and 75 age- and sex-matched controls. Ejection time was measured from the left ventricular outflow Doppler signal. The sum of isovolumic times was obtained by subtracting the ejection time from the interval between cessation and onset of mitral inflow measured from the mitral inflow velocity profile. The index was the sum of isovolumic times divided by ejection time. The values of the Doppler index in patients with idiopathic-dilated cardiomyopathy (0.85 ± 0.32) were significantly higher than values in controls (0.37 ± 0.08, p < 0.001). During follow-up of 5 years, 1 patient underwent cardiac transplantation and 36 patients died, 29 of cardiac, 5 of noncardiac, and 2 of unknown causes. Univariate analysis demonstrated that the Doppler index (chi-square = 18.3, p < 0.001), ejection fraction (chi-square = 15.2, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00559-1