Exercise capacity in hypertrophic cardiomyopathy depends on left ventricular diastolic function

Some studies have demonstrated that left ventricular (LV) diastolic function is the principal determinant of impaired exercise capacity in hypertrophic cardiomyopathy (HC). In this study we sought the capability of echocardiographic indexes of diastolic function in predicting exercise capacity in pa...

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Bibliographic Details
Published in:The American journal of cardiology 1999-08, Vol.84 (3), p.309-315
Main Authors: Briguori, Carlo, Betocchi, Sandro, Romano, Massimo, Manganelli, Fiore, Losi, Maria Angela, Ciampi, Quirino, Gottilla, Rossella, Lombardi, Raffaella, Condorelli, Mario, Chiariello, Massimo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Blood Flow Velocity
Cardiology
Cardiology. Vascular system
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - physiopathology
Cardiovascular disease
Diastole
Echocardiography, Doppler
Exercise
Exercise Test
Female
Heart
Heart Atria - diagnostic imaging
Humans
Linear Models
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Oxygen Consumption
Pulmonary Veins - diagnostic imaging
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
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Summary:Some studies have demonstrated that left ventricular (LV) diastolic function is the principal determinant of impaired exercise capacity in hypertrophic cardiomyopathy (HC). In this study we sought the capability of echocardiographic indexes of diastolic function in predicting exercise capacity in patients with HC. We studied 52 patients with HC while they were not on drugs;12 of them had LV tract obstruction at rest. Diastolic function was assessed by M-mode and Doppler echocardiography by measuring: (1) left atrial fractional shortening, and the slope of posterior aortic wall displacement during early atrial emptying on M-mode left atrial tracing; and (2) Doppler-derived transmitral and pulmonary venous flow velocity indexes. Exercise capacity was assessed by maximum oxygen consumption by cardiopulmonary test during cycloergometer upright exercise. Maximum oxygen consumption correlated with the left atrial fractional shortening (r = 0.63, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00282-9