Loading…

In Vivo Evidence That Endogenous Dopamine Modulates Sympathetic Activity in Man

Dopamine receptors type 2 (D2)-like receptor blockers cause an increase in the norepinephrine response to intense physical exercise. However, during intense physical exercise, D2-like antagonists also cause an increase in the epinephrine response, which itself might cause an increase in plasma norep...

Full description

Saved in:

Bibliographic Details
Published in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-09, Vol.34 (3), p.398-402
Main Authors:	Mannelli, Massimo, Ianni, Lucia, Lazzeri, Chiara, Castellani, Walter, Pupilli, Cinzia, Villa, Giorgio La, Barletta, Giuseppe, Serio, Mario, Franchi, Franco
Format:	Article
Language:	English
Subjects:	Adrenal Gland Diseases - metabolism Adrenal Gland Diseases - physiopathology Adult Biological and medical sciences Cross-Over Studies Domperidone - pharmacology Dopamine - blood Dopamine - physiology Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Double-Blind Method Female Fundamental and applied biological sciences. Psychology Heart Rate Humans Male Middle Aged Norepinephrine - blood Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Physical Exertion - physiology Receptors, Dopamine D2 - metabolism Reference Values Sympathetic Nervous System - physiology Vertebrates: nervous system and sense organs
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3
cites	cdi_FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3
container_end_page	402
container_issue	3
container_start_page	398
container_title	Hypertension (Dallas, Tex. 1979)
container_volume	34
creator	Mannelli, Massimo Ianni, Lucia Lazzeri, Chiara Castellani, Walter Pupilli, Cinzia Villa, Giorgio La Barletta, Giuseppe Serio, Mario Franchi, Franco
description	Dopamine receptors type 2 (D2)-like receptor blockers cause an increase in the norepinephrine response to intense physical exercise. However, during intense physical exercise, D2-like antagonists also cause an increase in the epinephrine response, which itself might cause an increase in plasma norepinephrine through the activation of β2 presynaptic receptors. Therefore, we evaluated the effect of domperidone, a D2-like antagonist, on the norepinephrine response to physical exercise in 6 Addison patients (3 were adrenalectomized and 3 had adrenal tuberculosis). In these patients, the norepinephrine increase observed during exercise was significantly higher after the administration of domperidone than a placebo (F=4,328; P
doi_str_mv	10.1161/01.HYP.34.3.398
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70046925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70046925</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3</originalsourceid><addsrcrecordid>eNpd0N9rFDEQB_Agir1Wn32TINK33eb3Jo-lnrbQUsEq-hTSvVkvdTc5k-yV--9NuQPFvAwZPjMMX4TeUNJSqugZoe3lj88tFy1vudHP0IJKJhohFX-OFoQa0RhKvx-h45wfCKFCiO4lOqJEaMO1WKDbq4C_-W3Ey61fQegB361dwcuwij8hxDnjD3HjJh8A38TVPLoCGX_ZTRtX1lB8j8_74re-7LAP-MaFV-jF4MYMrw_1BH39uLy7uGyubz9dXZxfN73olG60cFIOUlO456RTwBlX3BjGFO87bajUREnuOikEDDA4bkAaPQBjg5OOOH6CTvd7Nyn-niEXO_ncwzi6APVq2xEilGGywnf_wYc4p1Bvs4xIZhTloqKzPepTzDnBYDfJTy7tLCX2KWhLqK1BWy4stzXoOvH2sHa-n2D1j98nW8H7A3C5d-OQXOh9_uuMJox2lYk9e4xjgZR_jfMjJLsGN5a1JfUJVvOixhhi6q95amn-BxvHkxo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205296134</pqid></control><display><type>article</type><title>In Vivo Evidence That Endogenous Dopamine Modulates Sympathetic Activity in Man</title><source>EZB Electronic Journals Library</source><creator>Mannelli, Massimo ; Ianni, Lucia ; Lazzeri, Chiara ; Castellani, Walter ; Pupilli, Cinzia ; Villa, Giorgio La ; Barletta, Giuseppe ; Serio, Mario ; Franchi, Franco</creator><creatorcontrib>Mannelli, Massimo ; Ianni, Lucia ; Lazzeri, Chiara ; Castellani, Walter ; Pupilli, Cinzia ; Villa, Giorgio La ; Barletta, Giuseppe ; Serio, Mario ; Franchi, Franco</creatorcontrib><description>Dopamine receptors type 2 (D2)-like receptor blockers cause an increase in the norepinephrine response to intense physical exercise. However, during intense physical exercise, D2-like antagonists also cause an increase in the epinephrine response, which itself might cause an increase in plasma norepinephrine through the activation of β2 presynaptic receptors. Therefore, we evaluated the effect of domperidone, a D2-like antagonist, on the norepinephrine response to physical exercise in 6 Addison patients (3 were adrenalectomized and 3 had adrenal tuberculosis). In these patients, the norepinephrine increase observed during exercise was significantly higher after the administration of domperidone than a placebo (F=4,328; P<0.001). Because peripheral plasma norepinephrine does not reflect the sympathetic tone to the heart accurately, we evaluated the effect of domperidone administration (20 mg orally) on the sympathovagal balance, which was measured by the ratio between the high- and low-frequency components of heart rate variability, in 9 normal volunteers in the supine and sitting positions. When compared with placebo, domperidone caused a significant increase in the low/high frequency ratio (P<0.05) in the sitting position without modifying basal and stimulated norepinephrine plasma levels or blood pressure. These data support a role for endogenous dopamine in modulating norepinephrine release by human sympathetic nerves in vivo.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.34.3.398</identifier><identifier>PMID: 10489384</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adrenal Gland Diseases - metabolism ; Adrenal Gland Diseases - physiopathology ; Adult ; Biological and medical sciences ; Cross-Over Studies ; Domperidone - pharmacology ; Dopamine - blood ; Dopamine - physiology ; Dopamine Antagonists - pharmacology ; Dopamine D2 Receptor Antagonists ; Double-Blind Method ; Female ; Fundamental and applied biological sciences. Psychology ; Heart Rate ; Humans ; Male ; Middle Aged ; Norepinephrine - blood ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Physical Exertion - physiology ; Receptors, Dopamine D2 - metabolism ; Reference Values ; Sympathetic Nervous System - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1999-09, Vol.34 (3), p.398-402</ispartof><rights>1999 American Heart Association, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3</citedby><cites>FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1980217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10489384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mannelli, Massimo</creatorcontrib><creatorcontrib>Ianni, Lucia</creatorcontrib><creatorcontrib>Lazzeri, Chiara</creatorcontrib><creatorcontrib>Castellani, Walter</creatorcontrib><creatorcontrib>Pupilli, Cinzia</creatorcontrib><creatorcontrib>Villa, Giorgio La</creatorcontrib><creatorcontrib>Barletta, Giuseppe</creatorcontrib><creatorcontrib>Serio, Mario</creatorcontrib><creatorcontrib>Franchi, Franco</creatorcontrib><title>In Vivo Evidence That Endogenous Dopamine Modulates Sympathetic Activity in Man</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Dopamine receptors type 2 (D2)-like receptor blockers cause an increase in the norepinephrine response to intense physical exercise. However, during intense physical exercise, D2-like antagonists also cause an increase in the epinephrine response, which itself might cause an increase in plasma norepinephrine through the activation of β2 presynaptic receptors. Therefore, we evaluated the effect of domperidone, a D2-like antagonist, on the norepinephrine response to physical exercise in 6 Addison patients (3 were adrenalectomized and 3 had adrenal tuberculosis). In these patients, the norepinephrine increase observed during exercise was significantly higher after the administration of domperidone than a placebo (F=4,328; P<0.001). Because peripheral plasma norepinephrine does not reflect the sympathetic tone to the heart accurately, we evaluated the effect of domperidone administration (20 mg orally) on the sympathovagal balance, which was measured by the ratio between the high- and low-frequency components of heart rate variability, in 9 normal volunteers in the supine and sitting positions. When compared with placebo, domperidone caused a significant increase in the low/high frequency ratio (P<0.05) in the sitting position without modifying basal and stimulated norepinephrine plasma levels or blood pressure. These data support a role for endogenous dopamine in modulating norepinephrine release by human sympathetic nerves in vivo.</description><subject>Adrenal Gland Diseases - metabolism</subject><subject>Adrenal Gland Diseases - physiopathology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross-Over Studies</subject><subject>Domperidone - pharmacology</subject><subject>Dopamine - blood</subject><subject>Dopamine - physiology</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Norepinephrine - blood</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Physical Exertion - physiology</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Reference Values</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNpd0N9rFDEQB_Agir1Wn32TINK33eb3Jo-lnrbQUsEq-hTSvVkvdTc5k-yV--9NuQPFvAwZPjMMX4TeUNJSqugZoe3lj88tFy1vudHP0IJKJhohFX-OFoQa0RhKvx-h45wfCKFCiO4lOqJEaMO1WKDbq4C_-W3Ey61fQegB361dwcuwij8hxDnjD3HjJh8A38TVPLoCGX_ZTRtX1lB8j8_74re-7LAP-MaFV-jF4MYMrw_1BH39uLy7uGyubz9dXZxfN73olG60cFIOUlO456RTwBlX3BjGFO87bajUREnuOikEDDA4bkAaPQBjg5OOOH6CTvd7Nyn-niEXO_ncwzi6APVq2xEilGGywnf_wYc4p1Bvs4xIZhTloqKzPepTzDnBYDfJTy7tLCX2KWhLqK1BWy4stzXoOvH2sHa-n2D1j98nW8H7A3C5d-OQXOh9_uuMJox2lYk9e4xjgZR_jfMjJLsGN5a1JfUJVvOixhhi6q95amn-BxvHkxo</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Mannelli, Massimo</creator><creator>Ianni, Lucia</creator><creator>Lazzeri, Chiara</creator><creator>Castellani, Walter</creator><creator>Pupilli, Cinzia</creator><creator>Villa, Giorgio La</creator><creator>Barletta, Giuseppe</creator><creator>Serio, Mario</creator><creator>Franchi, Franco</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>In Vivo Evidence That Endogenous Dopamine Modulates Sympathetic Activity in Man</title><author>Mannelli, Massimo ; Ianni, Lucia ; Lazzeri, Chiara ; Castellani, Walter ; Pupilli, Cinzia ; Villa, Giorgio La ; Barletta, Giuseppe ; Serio, Mario ; Franchi, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenal Gland Diseases - metabolism</topic><topic>Adrenal Gland Diseases - physiopathology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross-Over Studies</topic><topic>Domperidone - pharmacology</topic><topic>Dopamine - blood</topic><topic>Dopamine - physiology</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Norepinephrine - blood</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Physical Exertion - physiology</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Reference Values</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mannelli, Massimo</creatorcontrib><creatorcontrib>Ianni, Lucia</creatorcontrib><creatorcontrib>Lazzeri, Chiara</creatorcontrib><creatorcontrib>Castellani, Walter</creatorcontrib><creatorcontrib>Pupilli, Cinzia</creatorcontrib><creatorcontrib>Villa, Giorgio La</creatorcontrib><creatorcontrib>Barletta, Giuseppe</creatorcontrib><creatorcontrib>Serio, Mario</creatorcontrib><creatorcontrib>Franchi, Franco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mannelli, Massimo</au><au>Ianni, Lucia</au><au>Lazzeri, Chiara</au><au>Castellani, Walter</au><au>Pupilli, Cinzia</au><au>Villa, Giorgio La</au><au>Barletta, Giuseppe</au><au>Serio, Mario</au><au>Franchi, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Evidence That Endogenous Dopamine Modulates Sympathetic Activity in Man</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1999-09</date><risdate>1999</risdate><volume>34</volume><issue>3</issue><spage>398</spage><epage>402</epage><pages>398-402</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Dopamine receptors type 2 (D2)-like receptor blockers cause an increase in the norepinephrine response to intense physical exercise. However, during intense physical exercise, D2-like antagonists also cause an increase in the epinephrine response, which itself might cause an increase in plasma norepinephrine through the activation of β2 presynaptic receptors. Therefore, we evaluated the effect of domperidone, a D2-like antagonist, on the norepinephrine response to physical exercise in 6 Addison patients (3 were adrenalectomized and 3 had adrenal tuberculosis). In these patients, the norepinephrine increase observed during exercise was significantly higher after the administration of domperidone than a placebo (F=4,328; P<0.001). Because peripheral plasma norepinephrine does not reflect the sympathetic tone to the heart accurately, we evaluated the effect of domperidone administration (20 mg orally) on the sympathovagal balance, which was measured by the ratio between the high- and low-frequency components of heart rate variability, in 9 normal volunteers in the supine and sitting positions. When compared with placebo, domperidone caused a significant increase in the low/high frequency ratio (P<0.05) in the sitting position without modifying basal and stimulated norepinephrine plasma levels or blood pressure. These data support a role for endogenous dopamine in modulating norepinephrine release by human sympathetic nerves in vivo.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>10489384</pmid><doi>10.1161/01.HYP.34.3.398</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0194-911X
ispartof	Hypertension (Dallas, Tex. 1979), 1999-09, Vol.34 (3), p.398-402
issn	0194-911X 1524-4563
language	eng
recordid	cdi_proquest_miscellaneous_70046925
source	EZB Electronic Journals Library
subjects	Adrenal Gland Diseases - metabolism Adrenal Gland Diseases - physiopathology Adult Biological and medical sciences Cross-Over Studies Domperidone - pharmacology Dopamine - blood Dopamine - physiology Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Double-Blind Method Female Fundamental and applied biological sciences. Psychology Heart Rate Humans Male Middle Aged Norepinephrine - blood Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Physical Exertion - physiology Receptors, Dopamine D2 - metabolism Reference Values Sympathetic Nervous System - physiology Vertebrates: nervous system and sense organs
title	In Vivo Evidence That Endogenous Dopamine Modulates Sympathetic Activity in Man
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T08%3A26%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vivo%20Evidence%20That%20Endogenous%20Dopamine%20Modulates%20Sympathetic%20Activity%20in%20Man&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Mannelli,%20Massimo&rft.date=1999-09&rft.volume=34&rft.issue=3&rft.spage=398&rft.epage=402&rft.pages=398-402&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/01.HYP.34.3.398&rft_dat=%3Cproquest_cross%3E70046925%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4768-84a55f581eb3076e32363992263c7891580653a7544efefa39e598fe22fa5a0a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=205296134&rft_id=info:pmid/10489384&rfr_iscdi=true