Biophysical Linkage between MRI and EEG Coherence in Closed Head Injury

Using conventional MRI procedures, nuclear magnetic resonance (NMR) of brain water proton (1H)T2 relaxation times and EEG coherence were obtained from two independent groups of closed head injured (CHI) patients and a group of normal control subjects. Statistically significant intercorrelations were...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 1998-11, Vol.8 (4), p.307-326
Main Authors: Thatcher, R.W., Biver, C., McAlaster, R., Salazar, A.
Format: Article
Language:English
Subjects:
1H proton relaxation times
Adolescent
Adult
Algorithms
Biophysical Phenomena
Biophysics
Brain - pathology
Brain - physiopathology
cognition
EEG coherence
Electroencephalography
Female
Head Injuries, Closed - pathology
Head Injuries, Closed - physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
MRI
Neuropsychological Tests
Reference Values
traumatic brain injury
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Summary:Using conventional MRI procedures, nuclear magnetic resonance (NMR) of brain water proton (1H)T2 relaxation times and EEG coherence were obtained from two independent groups of closed head injured (CHI) patients and a group of normal control subjects. Statistically significant intercorrelations were observed between1HT2 relaxation times of the cortical gray and white matter and EEG coherence. The analyses showed that lengthened1HT2 relaxation times of the cortical gray and white matter were related to: (1) decreased EEG coherence between short interelectrode distances (e.g., 7 cm) and increased EEG coherence between long interelectrode distances (e.g., 28 cm), (2) differences in EEG frequency in whichT2 relaxation time was most strongly related to the gray matter in the delta and theta frequencies in CHI patients, and (3) increasedT2 relaxation time and decreased short-distance EEG coherence were related to reduced cognitive function. The results were interpreted in terms of reduced integrity of protein/lipid neural membranes and the efficiency and effectiveness of short- and long-distance neural synchronization following traumatic brain injury.
ISSN:1053-8119
1095-9572
DOI:10.1006/nimg.1998.0365