Identification of a novel Drosophila SMAD on the X chromosome

TGF-beta signaling from the cell surface to the nucleus is mediated by the SMAD family of proteins, which have been grouped into three classes based upon sequence identity and function. Receptor-regulated, or pathway-restricted, SMADs (R-SMADs) are phosphorylated by ligand-specific serine/threonine...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1998-11, Vol.252 (1), p.195-201
Main Authors: Henderson, K.D. (The Johns Hopkins University School of Medicine, Baltimore, MD.), Andrew, D.J
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
BIOLOGICAL DEVELOPMENT
Body Patterning
Chromosome Mapping
DESARROLLO BIOLOGICO
DEVELOPPEMENT BIOLOGIQUE
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - genetics
Drosophila melanogaster
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila Proteins
Embryo, Nonmammalian - physiology
FACTEUR DE CROISSANCE TRANSFORMANT
FACTOR DE CRECIMIENTO TRANSFORMANTE
GENBANK/AF078529
In Situ Hybridization
MOLECULAR SEQUENCE DATA
Repressor Proteins
Sequence Alignment
Sequence Homology, Amino Acid
SIGNALING PROTEINS
Smad Proteins, Receptor-Regulated
Smad4 Protein
Trans-Activators - chemistry
Trans-Activators - genetics
Transcription Factors
TRANSFORMING GROWTH FACTOR
Transforming Growth Factor beta - physiology
Vertebrates
X Chromosome
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Summary:TGF-beta signaling from the cell surface to the nucleus is mediated by the SMAD family of proteins, which have been grouped into three classes based upon sequence identity and function. Receptor-regulated, or pathway-restricted, SMADs (R-SMADs) are phosphorylated by ligand-specific serine/threonine kinase receptors. Phosphorylated R-SMADs oligomerize with the coactivating, or shared, SMAD (Co-SMAD) mediator and translocate to the nucleus where the complex directs transcription of downstream target genes. Inhibitory SMADs (I-SMADs) block receptor-mediated phosphorylation of R-SMADs. In Drosophila, one member of each class of SMAD has been reported: MAD, an R-SMAD, MEDEA, a Co-SMAD, and DAD, an I-SMAD. Here, we report the first identification of a novel Drosophila R-SMAD, which we have named Smox for Smad on X. We have localized the Smox gene to a specific interval on the X chromosome and shown that Smox is transcribed throughout development.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1998.9562