Patterning Events and Specification Signals in the Developing Hippocampus

The mouse hippocampus is an attractive model system in which to study patterning of a cortical structure. Ongoing studies indicate that hippocampal areas or fields are specified many days before birth – possibly involving signals from within the cortical mantle. Although the hippocampal CA fields ar...

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Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 1999-09, Vol.9 (6), p.551-561
Main Authors: Grove, Elizabeth A., Tole, Shubha
Format: Article
Language:English
Subjects:
Age Factors
Animals
Biomarkers
Bone Morphogenetic Proteins - genetics
Cell Lineage - physiology
Cerebral Cortex - embryology
Female
Gene Expression Regulation, Developmental
Hippocampus - chemistry
Hippocampus - cytology
Hippocampus - embryology
In Situ Hybridization
Mice
Mice, Mutant Strains
Nerve Tissue Proteins - genetics
Neurons - chemistry
Neurons - cytology
Neurons - physiology
Octamer Transcription Factor-6
Pregnancy
Proto-Oncogene Proteins - genetics
Rats
Receptors, Kainic Acid - genetics
RNA, Messenger - analysis
Transcription Factors - genetics
Wnt Proteins
Zebrafish Proteins
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Summary:The mouse hippocampus is an attractive model system in which to study patterning of a cortical structure. Ongoing studies indicate that hippocampal areas or fields are specified many days before birth – possibly involving signals from within the cortical mantle. Although the hippocampal CA fields are distinguished by cytoarchitecture only after birth, molecular differences between fields appear by late gestation. Moreover, these embryonic fields are already specified to develop additional features that characterize the mature fields. The basic division of the hippocampus into fields may be specified still earlier. Thus, if medial cortical neuroepithelium is isolated in vitro early in hippocampal neurogenesis, it can autonomously generate features of a patterned hippocampus. In vivo, the spatial progression of initial field differentiation suggests that signals regulating growth and patterning could arise from sources close to the hippocampal poles. Observations of mouse mutants indicate that the cortical hem, an embryonic structure close to one pole of the hippocampus, is a source of such regulatory signals.
ISSN:1047-3211
1460-2199
1460-2199
DOI:10.1093/cercor/9.6.551