Markedly high prevalence of coronary risk factors in apparently healthy african-american and white siblings of persons with premature coronary heart disease

Among persons with a family history of premature coronary heart disease (CHD), siblings bear an excess risk of CHD that is as high as 12 times that of the general population. Aggressive, new, national guidelines for CHD risk reduction have focused on high-risk families, yet little is known about act...

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Bibliographic Details
Published in:The American journal of cardiology 1998-11, Vol.82 (9), p.1046-1051
Main Authors: Becker, Diane M, Yook, Raphael M, Moy, Taryn F, Blumenthal, Roger S, Becker, Lewis C
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Biological and medical sciences
Black or African American
Black People - genetics
Cardiology. Vascular system
Cardiovascular disease
Cholesterol, HDL - analysis
Cholesterol, LDL - analysis
Coronary Disease - epidemiology
Coronary Disease - genetics
Coronary heart disease
Female
Health risk assessment
Heart
Humans
Hypertension
Hypertriglyceridemia - blood
Hypertriglyceridemia - genetics
Male
Medical research
Medical sciences
Middle Aged
Reference Values
Risk Factors
Siblings
White People - genetics
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Summary:Among persons with a family history of premature coronary heart disease (CHD), siblings bear an excess risk of CHD that is as high as 12 times that of the general population. Aggressive, new, national guidelines for CHD risk reduction have focused on high-risk families, yet little is known about actual remediable risk factors in siblings of persons with premature CHD. To determine the magnitude of the problem relative to the general population, we screened 846 unaffected siblings (ages 30 to 59 years) of persons with documented CHD before age 60 years and compared their risk factor values with population reference norms obtained in the Third National Health and Nutrition Examination Survey (NHANES III) and the National Health Interview Survey (NHIS). Mean levels of low-density lipoprotein cholesterol were 0.52 mmol/L (20 mg/dl) higher in siblings; the prevalence of low-density lipoprotein cholesterol ≥4.14 mmol/L (160 mg/dl) was nearly twice that of race, sex, and age-specific values from NHANES III. Levels of high-density lipoprotein cholesterol
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(98)00553-0