Genital Human Papillomavirus Infection in Women Who Have Sex with Women

Genital infection with human papillomavirus (HPV), as determined by polymerase chain reaction detection of HPV DNA and prevalence of HPV-6 and -16 serum antibodies, was investigated in 149 women who were sexually active with women. By use of HPV L1 consensus primers and hybridization to types 6/11,...

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Bibliographic Details
Published in:The Journal of infectious diseases 1998-12, Vol.178 (6), p.1604-1609
Main Authors: Marrazzo, Jeanne M., Koutsky, Laura A., Stine, Kathleen L., Kuypers, Jane M., Grubert, Thomas A., Galloway, Denise A., Kiviat, Nancy B., Handsfield, H. Hunter
Format: Article
Language:English
Subjects:
Adult
Age Factors
Analysis of Variance
Antibodies
Biological and medical sciences
DNA Primers
DNA, Viral - isolation & purification
Female
Genitalia
Heterosexuality
Homosexuality, Female
Human papillomavirus 6
Human viral diseases
Humans
Infections
Infectious diseases
Lesbianism
Major Article
Male
Medical sciences
Men
Multivariate Analysis
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - transmission
Polymerase Chain Reaction
Referents
Risk Factors
Sexually transmitted diseases
Sexually Transmitted Diseases - transmission
Sexually Transmitted Diseases - virology
Software
Tumor Virus Infections - transmission
Viral diseases
Viral diseases of the genital and urinary system
Washington
Women
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Summary:Genital infection with human papillomavirus (HPV), as determined by polymerase chain reaction detection of HPV DNA and prevalence of HPV-6 and -16 serum antibodies, was investigated in 149 women who were sexually active with women. By use of HPV L1 consensus primers and hybridization to types 6/11, 16, 18, 31/33/35/39, and 45 and a generic probe, HPV DNA was detected in 30% of subjects; of these, 20% had type 31/33/35/39, 18% had type 16, and 2% had type 6/11. Of 21 subjects reporting no prior sex with men, HPV DNA was detected in 19% and squamous intraepithelial lesions in 14%. By capture ELISA with HPV-6 and -16 L1 capsids, 47% of subjects were seropositive for HPV-16 and 62% for HPV-6. Current smoking was associated with detectable HPV DNA. Genital HPV infection and squamous intraepithelial lesions are common among women who are sexually active with women and occur among those who have not had sex with men.
ISSN:0022-1899
1537-6613
DOI:10.1086/314494