Teriparatide and orthopedic surgery

Teriparatide has an anabolic effect on bone tissue, leading to an increase in bone strength with a reduction in the risk of fragility fractures in osteoporotic women. In the last ten years, many animal studies have been conducted to support the hypothesis that this anabolic effect of teriparatide ma...

Full description

Saved in:
Bibliographic Details
Published in:Aging clinical and experimental research 2007-08, Vol.19 (4 Suppl), p.22-25
Main Authors: Iolascon, Giovanni, Gimigliano, Francesca, Resmini, Giuseppina
Format: Article
Language:English
Subjects:
Animals
Bone Remodeling - drug effects
Bone Remodeling - physiology
Female
Fracture Healing - drug effects
Fractures, Spontaneous - prevention & control
Humans
Orthopedics - methods
Osteogenesis - drug effects
Osteogenesis - physiology
Parathyroid Hormone - pharmacology
Parathyroid Hormone - physiology
Prostheses and Implants
Rats
Teriparatide - pharmacology
Teriparatide - therapeutic use
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Teriparatide has an anabolic effect on bone tissue, leading to an increase in bone strength with a reduction in the risk of fragility fractures in osteoporotic women. In the last ten years, many animal studies have been conducted to support the hypothesis that this anabolic effect of teriparatide may benefit fracture healing by reducing the time of callus formation and remodeling. Teriparatide also seems to have an effect in the early post-operative period after osteosynthesis or joint replacement, by stimulating new bone formation, increasing bone-implant contact as early as after 1 week, and enhancing the tensile strength of the bone-cement interface, thereby decreasing the risk of late aseptic loosening. Scientific evidence supports the hypothesis that teriparatide may represent a huge resource for wide applications in orthopedic surgery.
ISSN:1594-0667