Inversion of chromosome 16 in accelerated phase of chronic myeloid leukaemia : report of a case and review of the literature

A patient with a Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) developed a blast crisis (FAB subtype AML-M2) without a monocytic involvement. Karyotype showed the presence of inv(16)(p13;q22) in addition to Ph, in 16/20 marrow metaphases.

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 1998-09, Vol.15 (3), p.199-201
Main Authors: COLOVIC, M, JANKOVIC, G, BILA, J, DJORDJEVIC, V, WIERNIK, P. H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blast Crisis
Chromosome Inversion
Chromosomes, Human, Pair 16 - genetics
Eosinophils
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Oncology
Philadelphia Chromosome
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Description
Summary:A patient with a Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) developed a blast crisis (FAB subtype AML-M2) without a monocytic involvement. Karyotype showed the presence of inv(16)(p13;q22) in addition to Ph, in 16/20 marrow metaphases.
ISSN:1357-0560
1559-131X
DOI:10.1007/BF02821939