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Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility
Initiating the chronic administration of progesterone to cattle during metoestrus will produce shortened oestrous cycles containing one or two wave-like sequences of ovarian follicle development. Conception rates are reduced to inseminations at the oestrus preceding these shortened cycles. In contra...
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| Published in: | Animal reproduction science 1999-08, Vol.56 (3), p.189-200 |
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| container_title | Animal reproduction science |
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| creator | Lynch, P.R Macmillan, K.L Taufa, V.K |
| description | Initiating the chronic administration of progesterone to cattle during metoestrus will produce shortened oestrous cycles containing one or two wave-like sequences of ovarian follicle development. Conception rates are reduced to inseminations at the oestrus preceding these shortened cycles. In contrast, a single injection of the GnRH analogue, buserelin, around mid-dioestrus can lengthen the oestrous cycle by increasing the proportion of cycles with three waves of follicular development and may also increase conception rates. A series of trials was conducted to test the hypothesis that the adverse effects of progesterone on oestrous cycle length and conception rate could be prevented with a strategic injection of GnRH. In Trial 1, progesterone was administered per vaginum to heifers for 10 days from Day 2 or 3 (Oestrus=Day 0) and with (
n=42) or without (
n=46) an injection of a GnRH analogue (10 μg buserelin) on Day 12 or 13. Other heifers (
n=44) served as an untreated control group. The average inter-oestrous interval (IOI) for those heifers treated only with progesterone was 17.0 days and was less (
p |
| doi_str_mv | 10.1016/S0378-4320(99)00044-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70056556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378432099000445</els_id><sourcerecordid>70056556</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-f10cf32b9fe83c902acc2f7e9065a3a446b4c077e829dd885ae4fa3b402334b33</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1ERbelP6HIJwSHwPgriU8IVdBWWhUJ2rPlOOPUKJsU20u1_x6nqRA3fJnDPDN-5yHknMEHBqz--ANE01ZScHin9XsAkLJSL8iGtY2oOBf8Jdn8RY7JSUo_C9TUtX5FjhlI3WimNuT-NqLNYRqoszmPSB9DvqcPcR4wZYzzhNQm-ojjuFRLL6fvV9ROdpyHfWl5jy4nOhc4zvtE3cGVHSNOQ9lip556jDmMIR9ekyNvx4Rnz_WU3H39cntxVW2_XV5ffN5WTrQiV56B84J32mMrnAZuneO-QQ21ssJKWXfSQdNgy3Xft62yKL0VnQQuhOyEOCVv173lhl_7ksvsQnIlv52wJDQNgKqVqguoVtDFOaWI3jzEsLPxYBiYRbF5UmwWf0Zr86TYqDL35vmDfbfD_p-p1WkBzlfA29nYIYZkbrYclscYLP1Pax-Lht8Bo0ku4OSwD7HYNP0c_hPhD5wqlPk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70056556</pqid></control><display><type>article</type><title>Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility</title><source>Elsevier</source><creator>Lynch, P.R ; Macmillan, K.L ; Taufa, V.K</creator><creatorcontrib>Lynch, P.R ; Macmillan, K.L ; Taufa, V.K</creatorcontrib><description>Initiating the chronic administration of progesterone to cattle during metoestrus will produce shortened oestrous cycles containing one or two wave-like sequences of ovarian follicle development. Conception rates are reduced to inseminations at the oestrus preceding these shortened cycles. In contrast, a single injection of the GnRH analogue, buserelin, around mid-dioestrus can lengthen the oestrous cycle by increasing the proportion of cycles with three waves of follicular development and may also increase conception rates. A series of trials was conducted to test the hypothesis that the adverse effects of progesterone on oestrous cycle length and conception rate could be prevented with a strategic injection of GnRH. In Trial 1, progesterone was administered per vaginum to heifers for 10 days from Day 2 or 3 (Oestrus=Day 0) and with (
n=42) or without (
n=46) an injection of a GnRH analogue (10 μg buserelin) on Day 12 or 13. Other heifers (
n=44) served as an untreated control group. The average inter-oestrous interval (IOI) for those heifers treated only with progesterone was 17.0 days and was less (
p<0.05) than the average intervals for those also receiving GnRH (20.2 days) or in the control group (20.0 days). In Trial 2, 45 heifers were inseminated following a synchronised oestrus. Progesterone was administered as in Trial 1 to 22 of the heifers. Their conception rate was 45.4% and this was less (
p<0.05) than the 73.9% obtained with their 23 untreated contemporaries. Trial 3 was completed using 530 cows in commercial dairyherds. The 259 cows receiving progesterone and GnRH (buserelin) after their first inseminations had a conception rate of 68.3% compared to 56.1% for their 271 untreated herdmates (
p<0.05%). Heifer calves born to treated cows had heavier birthweights (33.4 vs. 31.1 kg;
p<0.05), but birthweights of bull calves were unaffected (35.5 vs. 35.8 kg). Gestation lengths for cows conceiving to first inseminations were similar for treated and control groups (280.9 vs. 280.5 days). The results of these trials confirmed the hypothesis that a strategic injection of the GnRH analogue, buserelin, could prevent the reductions in oestrous cycle length and conception rate associated with the chronic metoestrous administration of progesterone.</description><identifier>ISSN: 0378-4320</identifier><identifier>EISSN: 1873-2232</identifier><identifier>DOI: 10.1016/S0378-4320(99)00044-5</identifier><identifier>PMID: 10497915</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Intravaginal ; Animals ; Animals, Newborn ; Birth Weight ; BOVIN ; Buserelin - administration & dosage ; Buserelin - pharmacology ; CATTLE ; Cattle - physiology ; CICLO ESTRAL ; Conception rate ; CYCLE OESTRAL ; Estrus - drug effects ; Estrus - physiology ; Female ; Fertility - drug effects ; Fertility Agents, Female - administration & dosage ; Fertility Agents, Female - pharmacology ; GANADO BOVINO ; GnRH ; GONADOLIBERINE ; GONADOTROPIN RELEASING HORMONE ; Gonadotropin-Releasing Hormone - therapeutic use ; HORMONA LIBERADORA DE GONADOTROPINA ; Male ; OESTROUS CYCLE ; Ovarian Follicle - physiology ; PERFORMANCE DE REPRODUCTION ; Pregnancy ; Pregnancy Rate ; PROGESTERONA ; PROGESTERONE ; Progesterone - administration & dosage ; Progesterone - blood ; Progesterone - pharmacology ; REPRODUCTIVE PERFORMANCE ; REPRODUCTIVIDAD</subject><ispartof>Animal reproduction science, 1999-08, Vol.56 (3), p.189-200</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-f10cf32b9fe83c902acc2f7e9065a3a446b4c077e829dd885ae4fa3b402334b33</citedby><cites>FETCH-LOGICAL-c383t-f10cf32b9fe83c902acc2f7e9065a3a446b4c077e829dd885ae4fa3b402334b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10497915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, P.R</creatorcontrib><creatorcontrib>Macmillan, K.L</creatorcontrib><creatorcontrib>Taufa, V.K</creatorcontrib><title>Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility</title><title>Animal reproduction science</title><addtitle>Anim Reprod Sci</addtitle><description>Initiating the chronic administration of progesterone to cattle during metoestrus will produce shortened oestrous cycles containing one or two wave-like sequences of ovarian follicle development. Conception rates are reduced to inseminations at the oestrus preceding these shortened cycles. In contrast, a single injection of the GnRH analogue, buserelin, around mid-dioestrus can lengthen the oestrous cycle by increasing the proportion of cycles with three waves of follicular development and may also increase conception rates. A series of trials was conducted to test the hypothesis that the adverse effects of progesterone on oestrous cycle length and conception rate could be prevented with a strategic injection of GnRH. In Trial 1, progesterone was administered per vaginum to heifers for 10 days from Day 2 or 3 (Oestrus=Day 0) and with (
n=42) or without (
n=46) an injection of a GnRH analogue (10 μg buserelin) on Day 12 or 13. Other heifers (
n=44) served as an untreated control group. The average inter-oestrous interval (IOI) for those heifers treated only with progesterone was 17.0 days and was less (
p<0.05) than the average intervals for those also receiving GnRH (20.2 days) or in the control group (20.0 days). In Trial 2, 45 heifers were inseminated following a synchronised oestrus. Progesterone was administered as in Trial 1 to 22 of the heifers. Their conception rate was 45.4% and this was less (
p<0.05) than the 73.9% obtained with their 23 untreated contemporaries. Trial 3 was completed using 530 cows in commercial dairyherds. The 259 cows receiving progesterone and GnRH (buserelin) after their first inseminations had a conception rate of 68.3% compared to 56.1% for their 271 untreated herdmates (
p<0.05%). Heifer calves born to treated cows had heavier birthweights (33.4 vs. 31.1 kg;
p<0.05), but birthweights of bull calves were unaffected (35.5 vs. 35.8 kg). Gestation lengths for cows conceiving to first inseminations were similar for treated and control groups (280.9 vs. 280.5 days). The results of these trials confirmed the hypothesis that a strategic injection of the GnRH analogue, buserelin, could prevent the reductions in oestrous cycle length and conception rate associated with the chronic metoestrous administration of progesterone.</description><subject>Administration, Intravaginal</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Birth Weight</subject><subject>BOVIN</subject><subject>Buserelin - administration & dosage</subject><subject>Buserelin - pharmacology</subject><subject>CATTLE</subject><subject>Cattle - physiology</subject><subject>CICLO ESTRAL</subject><subject>Conception rate</subject><subject>CYCLE OESTRAL</subject><subject>Estrus - drug effects</subject><subject>Estrus - physiology</subject><subject>Female</subject><subject>Fertility - drug effects</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertility Agents, Female - pharmacology</subject><subject>GANADO BOVINO</subject><subject>GnRH</subject><subject>GONADOLIBERINE</subject><subject>GONADOTROPIN RELEASING HORMONE</subject><subject>Gonadotropin-Releasing Hormone - therapeutic use</subject><subject>HORMONA LIBERADORA DE GONADOTROPINA</subject><subject>Male</subject><subject>OESTROUS CYCLE</subject><subject>Ovarian Follicle - physiology</subject><subject>PERFORMANCE DE REPRODUCTION</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>PROGESTERONA</subject><subject>PROGESTERONE</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - blood</subject><subject>Progesterone - pharmacology</subject><subject>REPRODUCTIVE PERFORMANCE</subject><subject>REPRODUCTIVIDAD</subject><issn>0378-4320</issn><issn>1873-2232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi1ERbelP6HIJwSHwPgriU8IVdBWWhUJ2rPlOOPUKJsU20u1_x6nqRA3fJnDPDN-5yHknMEHBqz--ANE01ZScHin9XsAkLJSL8iGtY2oOBf8Jdn8RY7JSUo_C9TUtX5FjhlI3WimNuT-NqLNYRqoszmPSB9DvqcPcR4wZYzzhNQm-ojjuFRLL6fvV9ROdpyHfWl5jy4nOhc4zvtE3cGVHSNOQ9lip556jDmMIR9ekyNvx4Rnz_WU3H39cntxVW2_XV5ffN5WTrQiV56B84J32mMrnAZuneO-QQ21ssJKWXfSQdNgy3Xft62yKL0VnQQuhOyEOCVv173lhl_7ksvsQnIlv52wJDQNgKqVqguoVtDFOaWI3jzEsLPxYBiYRbF5UmwWf0Zr86TYqDL35vmDfbfD_p-p1WkBzlfA29nYIYZkbrYclscYLP1Pax-Lht8Bo0ku4OSwD7HYNP0c_hPhD5wqlPk</recordid><startdate>19990816</startdate><enddate>19990816</enddate><creator>Lynch, P.R</creator><creator>Macmillan, K.L</creator><creator>Taufa, V.K</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990816</creationdate><title>Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility</title><author>Lynch, P.R ; Macmillan, K.L ; Taufa, V.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-f10cf32b9fe83c902acc2f7e9065a3a446b4c077e829dd885ae4fa3b402334b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Intravaginal</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Birth Weight</topic><topic>BOVIN</topic><topic>Buserelin - administration & dosage</topic><topic>Buserelin - pharmacology</topic><topic>CATTLE</topic><topic>Cattle - physiology</topic><topic>CICLO ESTRAL</topic><topic>Conception rate</topic><topic>CYCLE OESTRAL</topic><topic>Estrus - drug effects</topic><topic>Estrus - physiology</topic><topic>Female</topic><topic>Fertility - drug effects</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertility Agents, Female - pharmacology</topic><topic>GANADO BOVINO</topic><topic>GnRH</topic><topic>GONADOLIBERINE</topic><topic>GONADOTROPIN RELEASING HORMONE</topic><topic>Gonadotropin-Releasing Hormone - therapeutic use</topic><topic>HORMONA LIBERADORA DE GONADOTROPINA</topic><topic>Male</topic><topic>OESTROUS CYCLE</topic><topic>Ovarian Follicle - physiology</topic><topic>PERFORMANCE DE REPRODUCTION</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>PROGESTERONA</topic><topic>PROGESTERONE</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - blood</topic><topic>Progesterone - pharmacology</topic><topic>REPRODUCTIVE PERFORMANCE</topic><topic>REPRODUCTIVIDAD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, P.R</creatorcontrib><creatorcontrib>Macmillan, K.L</creatorcontrib><creatorcontrib>Taufa, V.K</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Animal reproduction science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, P.R</au><au>Macmillan, K.L</au><au>Taufa, V.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility</atitle><jtitle>Animal reproduction science</jtitle><addtitle>Anim Reprod Sci</addtitle><date>1999-08-16</date><risdate>1999</risdate><volume>56</volume><issue>3</issue><spage>189</spage><epage>200</epage><pages>189-200</pages><issn>0378-4320</issn><eissn>1873-2232</eissn><abstract>Initiating the chronic administration of progesterone to cattle during metoestrus will produce shortened oestrous cycles containing one or two wave-like sequences of ovarian follicle development. Conception rates are reduced to inseminations at the oestrus preceding these shortened cycles. In contrast, a single injection of the GnRH analogue, buserelin, around mid-dioestrus can lengthen the oestrous cycle by increasing the proportion of cycles with three waves of follicular development and may also increase conception rates. A series of trials was conducted to test the hypothesis that the adverse effects of progesterone on oestrous cycle length and conception rate could be prevented with a strategic injection of GnRH. In Trial 1, progesterone was administered per vaginum to heifers for 10 days from Day 2 or 3 (Oestrus=Day 0) and with (
n=42) or without (
n=46) an injection of a GnRH analogue (10 μg buserelin) on Day 12 or 13. Other heifers (
n=44) served as an untreated control group. The average inter-oestrous interval (IOI) for those heifers treated only with progesterone was 17.0 days and was less (
p<0.05) than the average intervals for those also receiving GnRH (20.2 days) or in the control group (20.0 days). In Trial 2, 45 heifers were inseminated following a synchronised oestrus. Progesterone was administered as in Trial 1 to 22 of the heifers. Their conception rate was 45.4% and this was less (
p<0.05) than the 73.9% obtained with their 23 untreated contemporaries. Trial 3 was completed using 530 cows in commercial dairyherds. The 259 cows receiving progesterone and GnRH (buserelin) after their first inseminations had a conception rate of 68.3% compared to 56.1% for their 271 untreated herdmates (
p<0.05%). Heifer calves born to treated cows had heavier birthweights (33.4 vs. 31.1 kg;
p<0.05), but birthweights of bull calves were unaffected (35.5 vs. 35.8 kg). Gestation lengths for cows conceiving to first inseminations were similar for treated and control groups (280.9 vs. 280.5 days). The results of these trials confirmed the hypothesis that a strategic injection of the GnRH analogue, buserelin, could prevent the reductions in oestrous cycle length and conception rate associated with the chronic metoestrous administration of progesterone.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10497915</pmid><doi>10.1016/S0378-4320(99)00044-5</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4320 |
| ispartof | Animal reproduction science, 1999-08, Vol.56 (3), p.189-200 |
| issn | 0378-4320 1873-2232 |
| language | eng |
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| source | Elsevier |
| subjects | Administration, Intravaginal Animals Animals, Newborn Birth Weight BOVIN Buserelin - administration & dosage Buserelin - pharmacology CATTLE Cattle - physiology CICLO ESTRAL Conception rate CYCLE OESTRAL Estrus - drug effects Estrus - physiology Female Fertility - drug effects Fertility Agents, Female - administration & dosage Fertility Agents, Female - pharmacology GANADO BOVINO GnRH GONADOLIBERINE GONADOTROPIN RELEASING HORMONE Gonadotropin-Releasing Hormone - therapeutic use HORMONA LIBERADORA DE GONADOTROPINA Male OESTROUS CYCLE Ovarian Follicle - physiology PERFORMANCE DE REPRODUCTION Pregnancy Pregnancy Rate PROGESTERONA PROGESTERONE Progesterone - administration & dosage Progesterone - blood Progesterone - pharmacology REPRODUCTIVE PERFORMANCE REPRODUCTIVIDAD |
| title | Treating cattle with progesterone as well as a GnRH analogue affects oestrous cycle length and fertility |
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