Comparison of rhG-CSF primed bone marrow and blood stem cell autografts: an analysis of engraftment in malignant lymphomas and solid tumours

:  Many studies have documented faster engraftment after transplantation with peripheral blood stem cells (PBSC) compared to bone marrow (BM) stem cells. Most comparisons, however, have been between unprimed BM and primed PBSC. We have collected engraftment data on 39 patients from 4 Danish centres...

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Bibliographic Details
Published in:European journal of haematology 1998-10, Vol.61 (4), p.229-234
Main Authors: Knudsen, Lene Meldgaard, Hansen, Steen Werner, Daugård, Gedske, Jarlbæk, Lene, Agerbæk, Mads, Jensen, Linda, Skovsgård, Torben, Hansen, Flemming, Johnsen, Hans E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antigens, CD34
Biological and medical sciences
blood stem cell transplantation
Bone Marrow Transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
engraftment
G-CSF
Graft Survival
Granulocyte Colony-Stimulating Factor - pharmacology
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma - therapy
Male
Medical sciences
Middle Aged
Recombinant Proteins - pharmacology
stem cell mobilization
Testicular Neoplasms - therapy
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation, Autologous
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Summary::  Many studies have documented faster engraftment after transplantation with peripheral blood stem cells (PBSC) compared to bone marrow (BM) stem cells. Most comparisons, however, have been between unprimed BM and primed PBSC. We have collected engraftment data on 39 patients from 4 Danish centres and compared G–CSF primed BM with G–CSF primed PBSC in malignant lymphoma and solid tumours. In the lymphoma group 6 BM transplants were compared with 8 PBSC transplants, whereas in the testicular cancer group 16 BM transplants were compared with 9 PBSC transplants. In the lymphoma group, the time to platelet engraftment (platelets >20times109/l unsupported) was median 15 d in PBSC transplants and median 34 d in BM transplants (p=0.003). In the solid tumour patients the difference in time to platelet engraftment was 11 and 18 d in PBSC and BM transplants, respectively (p
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.1998.tb01707.x