Analysis of the length distribution of murein glycan strands in ftsZ and ftsI mutants of E. coli

Abstract The chain length distribution of murein glycan strands was analyzed in wild-type cells and in cells in which preseptal and/or septal murein synthesis was prevented in ftsZ84 and ftsI36 mutants of E. coli. This revealed a significant change in glycan chain lengths in newly synthesized murein...

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Bibliographic Details
Published in:FEMS microbiology letters 1998-11, Vol.168 (1), p.71-75
Main Authors: Ishidate, Kohei, Ursinus, A, Höltje, Joachim-Volker, Rothfield, Lawrence
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Bacteriology
Biogenesis of cell structures, supramolecular organization
Biological and medical sciences
Biosynthesis
Carrier Proteins
Cell Division
Chains
Chromatography, High Pressure Liquid
Cytoskeletal Proteins
Deactivation
E coli
Escherichia coli
Escherichia coli - genetics
Escherichia coli - growth & development
Escherichia coli - metabolism
FtsZ gene
Fundamental and applied biological sciences. Psychology
Glycan
Hexosyltransferases - genetics
Inactivation
Microbiology
Multienzyme Complexes - genetics
Muramoylpentapeptide Carboxypeptidase
Murein
Mutation
Penicillin
Penicillin-Binding Proteins
Peptidoglycan - biosynthesis
Peptidoglycan - chemistry
Peptidoglycans
Peptidyl Transferases - genetics
Strands
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Summary:Abstract The chain length distribution of murein glycan strands was analyzed in wild-type cells and in cells in which preseptal and/or septal murein synthesis was prevented in ftsZ84 and ftsI36 mutants of E. coli. This revealed a significant change in glycan chain lengths in newly synthesized murein associated with inactivation of the ftsZ gene product but not with inactivation of the ftsI gene product. This is the first reported abnormality in murein biosynthesis associated with mutation of an essential cell division gene.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1998.tb13257.x