Chlamydia pneumoniae-based atherosclerosis: a smoking gun

Chronic and acute infectious diseases have been implicated in modifying the risk of atherosclerosis independently or in collaboration with conventional risk factors. During the past two decades, the discussion on microbial agents and atherosclerosis has mainly been centred on Chlamydia pneumo-niae.T...

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Bibliographic Details
Published in:Acta Cardiologica 2007-12, Vol.62 (6), p.565-571
Main Authors: Hoymans, Vicky Y., Bosmans, Johan M., Ieven, Margareta M., Vrints, Christiaan J.
Format: Article
Language:English
Subjects:
atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - immunology
Atherosclerosis - microbiology
Chlamydophila Infections - diagnosis
Chlamydophila Infections - drug therapy
Chlamydophila Infections - immunology
Chlamydophila pneumoniae - immunology
Chlamydophila pneumoniae - pathogenicity
Chlamydophila pneumoniae - ultrastructure
Humans
infection
Pilot Projects
Randomized Controlled Trials as Topic
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Summary:Chronic and acute infectious diseases have been implicated in modifying the risk of atherosclerosis independently or in collaboration with conventional risk factors. During the past two decades, the discussion on microbial agents and atherosclerosis has mainly been centred on Chlamydia pneumo-niae.The strongest evidence linking Chlamydia pneumoniae and atherosclerotic disease comes from in vitro experimental studies. In this review, we summarize and critically evaluate the available data of human diagnostic and therapeutic studies on the association of Chlamydia pneumoniae with ath-erosclerosis.Taking into account the human in vivo data, there is currently insufficient proof linking Chlamydia pneumoniae to atherosclerosis.At present, there are no indications for antibiotic treatment targeted at Chlamydia pneumoniae in the management of atherosclerosis.
ISSN:0001-5385
1784-973X
0001-5385
DOI:10.2143/AC.62.6.2024015