Toward a generalizable model of symptoms in major depressive disorder

Background: This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1998-11, Vol.44 (10), p.959-972
Main Authors: Gullion, Christina M, Rush, A.John
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
content coverage
Depression
Depressive Disorder - psychology
factor analysis
Factor Analysis, Statistical
Female
Humans
Major depressive disorder
Male
Medical sciences
Models, Psychological
Mood disorders
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
rating scales
symptom profiles
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Summary:Background: This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the Hamilton Depression Rating Scale (HDRS) and Beck Depression Inventory (BDI). Methods: A factor analysis of IDS-C, IDS-SR, HDRS, and BDI items was carried out on 324 adult outpatients with MDD. Patients with coexisting Axis I or III illness or those taking psychotropic medication were excluded. Results: Ten primary factors were identified, six of which were substantially intercorrelated, defining a second-order factor of general depression severity. Schmid–Leiman orthogonalization identified the symptoms most associated with general severity. Conclusions: The IDS provided more complete factor coverage than did the HDRS or BDI and thus may be more useful in research on symptom profiles.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(98)00235-2