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Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection

Objective: The study’s objective was to determine and correlate amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in patients with and without intra-amniotic infection. Study Design: Amniocentesis was performed on 41 pregnant women with preterm contractions, labor...

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Published in:American journal of obstetrics and gynecology 1998-11, Vol.179 (5), p.1267-1270
Main Authors: Hsu, Chaur-Dong, Meaddough, Erika, Aversa, Kristen, Hong, Shih-Fen, Lu, Li-Cheng, Jones, David C., Copel, Joshua A.
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container_title American journal of obstetrics and gynecology
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Meaddough, Erika
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Hong, Shih-Fen
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description Objective: The study’s objective was to determine and correlate amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in patients with and without intra-amniotic infection. Study Design: Amniocentesis was performed on 41 pregnant women with preterm contractions, labor, or premature rupture of membranes. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture result. Amniotic fluid tests for Gram stain, glucose, leukocyte counts, creatinine level, pH, and specific gravity were performed. Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were measured by an enzyme-linked immunoassay. Unlike in previous reports, cytokines were normalized by amniotic fluid creatinine levels. Results: Fifteen patients had intra-amniotic infection and 26 did not. Amniotic fluid median levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were significantly higher in pregnant women with intra-amniotic infection than in those without intra-amniotic infection (leukemia inhibitory factor median 3912 pg/mg creatinine, range 0.0-199314, vs 56 pg/mg creatinine, range 0.0-12148, P = .01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P = .005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P = .005). Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were positively correlated. Conclusions: The data indicate that leukemia inhibitory factor plays an important role in the pathogenesis of intra-amniotic infection. In addition, significant elevations of and correlations among amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 suggest that measurements of these cytokines in amniotic fluid may be of diagnostic and prognostic importance. (Am J Obstet Gynecol 1998;179:1267-70.)
doi_str_mv 10.1016/S0002-9378(98)70144-9
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Study Design: Amniocentesis was performed on 41 pregnant women with preterm contractions, labor, or premature rupture of membranes. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture result. Amniotic fluid tests for Gram stain, glucose, leukocyte counts, creatinine level, pH, and specific gravity were performed. Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were measured by an enzyme-linked immunoassay. Unlike in previous reports, cytokines were normalized by amniotic fluid creatinine levels. Results: Fifteen patients had intra-amniotic infection and 26 did not. Amniotic fluid median levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were significantly higher in pregnant women with intra-amniotic infection than in those without intra-amniotic infection (leukemia inhibitory factor median 3912 pg/mg creatinine, range 0.0-199314, vs 56 pg/mg creatinine, range 0.0-12148, P = .01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P = .005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P = .005). Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were positively correlated. Conclusions: The data indicate that leukemia inhibitory factor plays an important role in the pathogenesis of intra-amniotic infection. In addition, significant elevations of and correlations among amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 suggest that measurements of these cytokines in amniotic fluid may be of diagnostic and prognostic importance. (Am J Obstet Gynecol 1998;179:1267-70.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(98)70144-9</identifier><identifier>PMID: 9822513</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Amniotic fluid ; Amniotic Fluid - chemistry ; Amniotic Fluid - microbiology ; Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Female ; Growth Inhibitors - analysis ; Gynecology. Andrology. Obstetrics ; Humans ; Infection - metabolism ; interleukin 6 ; interleukin 8 ; Interleukin-6 - analysis ; Interleukin-8 - analysis ; intra-amniotic infection ; Leukemia Inhibitory Factor ; Lymphokines - analysis ; Medical sciences ; Osmolar Concentration ; Pregnancy ; Pregnancy. Fetus. 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Study Design: Amniocentesis was performed on 41 pregnant women with preterm contractions, labor, or premature rupture of membranes. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture result. Amniotic fluid tests for Gram stain, glucose, leukocyte counts, creatinine level, pH, and specific gravity were performed. Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were measured by an enzyme-linked immunoassay. Unlike in previous reports, cytokines were normalized by amniotic fluid creatinine levels. Results: Fifteen patients had intra-amniotic infection and 26 did not. Amniotic fluid median levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were significantly higher in pregnant women with intra-amniotic infection than in those without intra-amniotic infection (leukemia inhibitory factor median 3912 pg/mg creatinine, range 0.0-199314, vs 56 pg/mg creatinine, range 0.0-12148, P = .01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P = .005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P = .005). Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were positively correlated. Conclusions: The data indicate that leukemia inhibitory factor plays an important role in the pathogenesis of intra-amniotic infection. In addition, significant elevations of and correlations among amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 suggest that measurements of these cytokines in amniotic fluid may be of diagnostic and prognostic importance. (Am J Obstet Gynecol 1998;179:1267-70.)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Amniotic fluid</subject><subject>Amniotic Fluid - chemistry</subject><subject>Amniotic Fluid - microbiology</subject><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Growth Inhibitors - analysis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infection - metabolism</subject><subject>interleukin 6</subject><subject>interleukin 8</subject><subject>Interleukin-6 - analysis</subject><subject>Interleukin-8 - analysis</subject><subject>intra-amniotic infection</subject><subject>Leukemia Inhibitory Factor</subject><subject>Lymphokines - analysis</subject><subject>Medical sciences</subject><subject>Osmolar Concentration</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. 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Placenta</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Chaur-Dong</creatorcontrib><creatorcontrib>Meaddough, Erika</creatorcontrib><creatorcontrib>Aversa, Kristen</creatorcontrib><creatorcontrib>Hong, Shih-Fen</creatorcontrib><creatorcontrib>Lu, Li-Cheng</creatorcontrib><creatorcontrib>Jones, David C.</creatorcontrib><creatorcontrib>Copel, Joshua A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Chaur-Dong</au><au>Meaddough, Erika</au><au>Aversa, Kristen</au><au>Hong, Shih-Fen</au><au>Lu, Li-Cheng</au><au>Jones, David C.</au><au>Copel, Joshua A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>179</volume><issue>5</issue><spage>1267</spage><epage>1270</epage><pages>1267-1270</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: The study’s objective was to determine and correlate amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in patients with and without intra-amniotic infection. Study Design: Amniocentesis was performed on 41 pregnant women with preterm contractions, labor, or premature rupture of membranes. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture result. Amniotic fluid tests for Gram stain, glucose, leukocyte counts, creatinine level, pH, and specific gravity were performed. Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were measured by an enzyme-linked immunoassay. Unlike in previous reports, cytokines were normalized by amniotic fluid creatinine levels. Results: Fifteen patients had intra-amniotic infection and 26 did not. Amniotic fluid median levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were significantly higher in pregnant women with intra-amniotic infection than in those without intra-amniotic infection (leukemia inhibitory factor median 3912 pg/mg creatinine, range 0.0-199314, vs 56 pg/mg creatinine, range 0.0-12148, P = .01; interleukin 6 median 2005 ng/mg creatinine, range 27-4071, vs 990 ng/mg creatinine, range 7.5-3409, P = .005; interleukin 8: median 4933 ng/mg creatinine, range 0.0-55058, vs 61 ng/mg creatinine, range 0.0-2399, P = .005). Amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 were positively correlated. Conclusions: The data indicate that leukemia inhibitory factor plays an important role in the pathogenesis of intra-amniotic infection. In addition, significant elevations of and correlations among amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 suggest that measurements of these cytokines in amniotic fluid may be of diagnostic and prognostic importance. (Am J Obstet Gynecol 1998;179:1267-70.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>9822513</pmid><doi>10.1016/S0002-9378(98)70144-9</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Amniotic fluid
Amniotic Fluid - chemistry
Amniotic Fluid - microbiology
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Female
Growth Inhibitors - analysis
Gynecology. Andrology. Obstetrics
Humans
Infection - metabolism
interleukin 6
interleukin 8
Interleukin-6 - analysis
Interleukin-8 - analysis
intra-amniotic infection
Leukemia Inhibitory Factor
Lymphokines - analysis
Medical sciences
Osmolar Concentration
Pregnancy
Pregnancy. Fetus. Placenta
Reference Values
title Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection
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