Role of radioimmunolocalization in the staging of gastric carcinoma

Intraoperative radioimmunolocalization is a potentially useful technique for staging gastric neoplasms without resorting to extensive surgical intervention. Before preoperative immunohistochemical typing for the presence or absence of tumor‐associated glycoprotein (TAG) 72, we performed intraoperati...

Full description

Saved in:
Bibliographic Details
Published in:Seminars in surgical oncology 1998-12, Vol.15 (4), p.209-211
Main Authors: Mussa, Antonio, Sandrucci, Sergio, Mobiglia, Alberto, Baccega, Massimo, Mussa, Baudolino, De Filippi, Pier Giuseppe
Format: Article
Language:English
Subjects:
adenocarcinoma
Antibodies, Monoclonal
Antigens, Neoplasm - analysis
carcinoembryonic antigen
Carcinoma - diagnostic imaging
Carcinoma - pathology
Carcinoma - surgery
Glycoproteins - analysis
Humans
Immunohistochemistry
Indium Radioisotopes
lymph node excision
lymph node metastasis
Lymphatic Metastasis
monoclonal antibodies
Neoplasm Staging
Radioimmunodetection
Sensitivity and Specificity
stomach neoplasms
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
survival rate
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intraoperative radioimmunolocalization is a potentially useful technique for staging gastric neoplasms without resorting to extensive surgical intervention. Before preoperative immunohistochemical typing for the presence or absence of tumor‐associated glycoprotein (TAG) 72, we performed intraoperative radioimmunodetection on three patients presenting with gastric carcinoma using a whole monoclonal antibody (B72.3) marked with Indium‐111 injected 1 week before operation. The results were calculated on the number of lymph node stations and yielded a high sensitivity due to a specificity of 72% and the absence of false negatives. Intraoperative radioimmunolocalization is a promising method for noninvasive staging of both early and advanced gastric carcinoma. Semin. Surg. Oncol. 15:209–211, 1998. © 1998 Wiley‐Liss, Inc.
ISSN:8756-0437
1098-2388
DOI:10.1002/(SICI)1098-2388(199812)15:4<209::AID-SSU3>3.0.CO;2-D