Decreased bone mineral density in pre-menopause women with prolactinoma

Tumoral hyperprolactinemia and consequent hypogonadism have been associated with osteoporosis. Bone mineral density (BMD) was measured by dual-energy RX absorptiometry in 24 patients with prolactinoma (15 macro and 9 micro adenomas; age range = 18 to 49 years). Student unpaired t or Mann-Whitney tes...

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Published in:Arquivos brasileiros de endocrinologia e metabologia 2007-12, Vol.51 (9), p.1522-1527
Main Authors: Bussade, Isabela, Naliato, Erika C O, Mendonça, Laura Maria C, Violante, Alice H D, Farias, Maria Lucia F
Format: Article
Language:Portuguese
Subjects:
Adolescent
Adult
Bone Density - physiology
Confidence Intervals
Cross-Sectional Studies
Densitometry
Female
Humans
Hyperprolactinemia - complications
Hyperprolactinemia - physiopathology
Menstrual Cycle
Menstruation
Middle Aged
Osteoporosis - complications
Osteoporosis - physiopathology
Pituitary Neoplasms - complications
Pituitary Neoplasms - physiopathology
Premenopause - physiology
Prolactinoma - complications
Prolactinoma - physiopathology
Statistics, Nonparametric
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Summary:Tumoral hyperprolactinemia and consequent hypogonadism have been associated with osteoporosis. Bone mineral density (BMD) was measured by dual-energy RX absorptiometry in 24 patients with prolactinoma (15 macro and 9 micro adenomas; age range = 18 to 49 years). Student unpaired t or Mann-Whitney tests were used to compare groups, and Spearman test studied correlations. Lumbar spine (LS) was the most affected, as LS Z-score was < -2 SD in 20.83% of the patients. No difference was found in densitometric parameters for the comparison between macro and microprolactinoma, or those with normal prolactin versus hyperprolactinemia. LS BMD and LS Z-score were higher in the patients with > 8 menstrual cycles in the preceding year then in those with oligoamenorrhea (p = 0.030). The number of cycles was correlated to LS BMD (r = 0.515, p = 0.017) and body mass index to femoral neck BMD (r = 0.563, p = 0.006) and total femur BMD (r = 0.529, p = 0.011). Decreased bone mineral density was detected in 20.83% of our young patients with prolactinoma. The great involvement of trabecular bone skeletal regions, such as vertebrae, suggests the participation of hypogonadism in the pathogenesis of bone disease. Irrespective of prolactin levels, return to normal menses seems the best index of good control.
ISSN:0004-2730
DOI:10.1590/S0004-27302007000900016