Telomerase activity in lung cancer cell lines and tissues

Using TRAP assay, we studied the activity of the telomerase in the lung cancer cell lines, and lung cancer and normal tissues in which expression appears to be related to the immortality of cancer cells. All the human lung cancer cell lines and the majority of human lung cancer tissues (78%) express...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 1998-08, Vol.21 (2), p.99-103
Main Authors: Cheol Lee, Jae, Jong, Hyun-Soon, Yoo, Chul-Gyu, Koo Han, Sung, Shim, Young-Soo, Whan Kim, Young
Format: Article
Language:English
Subjects:
Biological and medical sciences
Humans
Lung - enzymology
Lung cancer
Lung Neoplasms - enzymology
Medical sciences
Neoplasm Proteins - metabolism
Pneumology
Reference Values
Telomerase
Telomerase - metabolism
Telomere
TRAP
Tumor Cells, Cultured
Tumors of the respiratory system and mediastinum
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Summary:Using TRAP assay, we studied the activity of the telomerase in the lung cancer cell lines, and lung cancer and normal tissues in which expression appears to be related to the immortality of cancer cells. All the human lung cancer cell lines and the majority of human lung cancer tissues (78%) expressed telomerase activity, but this was undetectable in normal human lung tissues. Positivity for telomerase activity in lung cancer cell lines was higher than in lung cancer tissues; this result implies the expression of telomerase activity may play a crucial role in the development or progression of lung cancer, and also suggests that improved method of detection may lead to the higher positivity for telomerase activity in primary lung cancer tissues. To determine whether there is a definite causal relationship between telomerase and cancer, and to develop new anti-cancer agents which inhibit telomerase, further study is needed.
ISSN:0169-5002
1872-8332
DOI:10.1016/S0169-5002(98)00034-8