Nasal scraping in diagnosing ciliary dyskinesia

Primary ciliary dyskinesia (PCD) is a congenital, clinically and ultrastructurally heterogeneous disease caused by abnormal structure and/or function of cilia. Kartagener's syndrome is one subgroup of PCD. Acquired ciliary dyskinesia is frequent, generally being associated with or following res...

Full description

Saved in:
Bibliographic Details
Published in:American journal of rhinology 2007-11, Vol.21 (6), p.702-705
Main Authors: Caruso, Giuseppi, Gelardi, Matteo, Passali, Giulio C, de Santi, Maria M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Cilia - ultrastructure
Epithelium - ultrastructure
Female
Humans
Kartagener Syndrome - diagnosis
Kartagener Syndrome - ultrastructure
Male
Microscopy, Electron, Transmission
Microtubules
Middle Aged
Mucociliary Clearance
Nasal Mucosa - ultrastructure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Primary ciliary dyskinesia (PCD) is a congenital, clinically and ultrastructurally heterogeneous disease caused by abnormal structure and/or function of cilia. Kartagener's syndrome is one subgroup of PCD. Acquired ciliary dyskinesia is frequent, generally being associated with or following respiratory tract infections. From January 2003 to April 2006, nasal mucociliary transport time was measured in 64 patients and specimens obtained by nasal scraping were examined by transmission electron microscope (TEM). The 64 nasal scrapings led to the diagnosis of 11 (17.2%) cases of PCD and 51 (79.7%) cases of secondary ciliary disorder. In two cases (3.1%) no clear diagnosis was possible. Nasal scraping is an easy, cheap, and efficient tool for detecting ciliary abnormalities by TEM and for distinguishing acquired and congenital modifications.
ISSN:1050-6586
1945-8924
1539-6290
1945-8932
DOI:10.2500/ajr.2007.21.3107