Lack of bcl-2 Persistence: An Independent Prognostic Indicator of Poor Prognosis in Endometrial Carcinoma

• Published in: Gynecologic oncology 1998-11, Vol.71 (2), p.305-307
• Main Authors: Geisler, John P., Geisler, Hans E., Wiemann, Michael C., Zhou, Zhen, Miller, Greg A., Crabtree, William
• Format: Article
• Language: English
• Subjects: bcl-2; Biological and medical sciences; endometrial cancer; Endometrial Neoplasms - chemistry; Endometrial Neoplasms - pathology; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins c-bcl-2 - analysis; recurrence; Tumors
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1006/gyno.1998.5192

Objective.bcl-2 is a protein which prohibits programmed cell death. The purpose of this study was to determine whether bcl-2 staining was related to traditional prognostic factors and/or recurrence in patients with endometrial carcinoma. Methods.One hundred twenty consecutively surgically treated patients with endometrial carcinoma had their tumors studied immunohistochemically for bcl-2 staining. Results.The mean follow-up of the patients was 53 months with a median of 56 months (range 30 to 68 months). bcl-2 staining was positive in 44.0% of patients with endometrioid carcinomas and in 23.1% of patients with nonendometrioid carcinomas (P< 0.001). Increasing depth of invasion (P= 0.014), grade (P= 0.011), and FIGO stage (P= 0.018) were each correlated with decreasing bcl-2 staining. bcl-2 staining was positive in 44.1% of patients whose tumors showed no lymphovascular space invasion and in 11.1% of patients with lymphovascular space invasion (P< 0.001). Only 1 of 26 patients with recurrent disease had persistence of bcl-2 staining. Multivariate analysis revealed FIGO stage (P= 0.0051), histologic grade (P= 0.050), and lack of staining for bcl-2 (P= 0.012) to be independent predictors of recurrence. Conclusion.bcl-2 persistence is more common in endometrioid than in nonendometrioid adenocarcinomas of the endometrium. It appears to be inversely correlated with the universally recognized prognostic factors of depth of invasion, histologic grade, and FIGO stage. Lack of bcl-2 persistence was an independent predictor of recurrence of disease. This group of patients continues to be followed to determine the role of bcl-2 persistence or lack of persistence as a predictor of 5-year survival of patients with endometrial carcinoma.