Helicobacter pylori Colonization in Infants and Young Children is Not Necessarily Associated with Diarrhoea

A cohort of 151 infants and young children aged 1–23 months from a poor peri-urban community of Bangladesh was studied to determine the relationship between Helicobacter pylori colonization and morbidity due to diarrhoea. A 13C urea breath test was performed to detect the presence of H. pylori.Child...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1998-10, Vol.44 (5), p.283-287
Main Authors: Rahman, M. M., Mahalanabis, D., Sarker, S. A., Bardhan, P. K., Alvarez, J. O., Hildebrand, P., Beglinger, C., Gyr, Klaus
Format: Article
Language:English
Subjects:
Bangladesh - epidemiology
Biological and medical sciences
Breath Tests
Chi-Square Distribution
Cohort Studies
Diarrhea - microbiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - complications
Helicobacter Infections - diagnosis
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Infant
Male
Medical sciences
Other diseases. Semiology
Statistics, Nonparametric
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tropical medicine
Urban Population
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Summary:A cohort of 151 infants and young children aged 1–23 months from a poor peri-urban community of Bangladesh was studied to determine the relationship between Helicobacter pylori colonization and morbidity due to diarrhoea. A 13C urea breath test was performed to detect the presence of H. pylori.Children were followed up at home every alternate day for 6 months and diarrhoeal morbidity datawere collected. Diarrhoeal morbidity was compared between H. pylori-positive and H. pylori-negative children. Sixty-eight (45 per cent) children were H. pylori positive and 83 (55 per cent) were H. pylori negative. During the first 1-month period following the breath test, three (4.4 per cent) H. pylori-positive and four (4.8 per cent) H. pylori-negative children had diarrhoea. Thirty-two (47 per cent) of the children in the positive group and 43 (52 per cent) in the negative group had one or more episodesof diarrhoea during the 6-month follow-up period. Median number of diarrhoeal episodes was 1.0(range 1.0–4.0) in the H. pylori-positive children and 2.0 (range 1.0–5.0) in the H. pylori-negativechildren (p = 0.19). No significant difference was observed in the cumulative days with diarrhoea.The results of this study suggest that H. pylori colonization is not associated with diarrhoealmorbidity in infants and young children.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/44.5.283