Genetic Characterization of the Murine Ym1 Gene and Identification of a Cluster of Highly Homologous Genes

The murine Ym1 gene belongs to a family of mammalian genes that are homologous to the chitinases from lower organisms, such as insects, nematodes, bacteria, and plants. All of these homologous mammalian proteins (except one member) have no demonstrable chitinase activity and therefore cannot be cons...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-12, Vol.54 (2), p.316-322
Main Authors: Jin, H.M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kirkpatrick, R.B., Rosenberg, M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Carrier Proteins - genetics
Chitinases - genetics
Chromosome Mapping
Chromosomes - genetics
Cloning, Molecular
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - genetics
Genes. Genome
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Receptors, Cell Surface
RNA Splicing - genetics
RNA, Messenger - genetics
Sequence Analysis, DNA
Sequence Homology, Amino Acid
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Summary:The murine Ym1 gene belongs to a family of mammalian genes that are homologous to the chitinases from lower organisms, such as insects, nematodes, bacteria, and plants. All of these homologous mammalian proteins (except one member) have no demonstrable chitinase activity and therefore cannot be considered chitinases. The biological functions of these proteins remain unknown. However, these proteins may function through binding to carbohydrate polymers. In an effort to characterize the murine Ym1 gene better, we have delineated its genomic structure. We mapped the chromosomal location of the Ym1 gene to a central region of mouse chromosome 3 (in the region syntenic to human chromosome 1p13) and that of another murine chitinase-like gene, Brp39, to a central region of mouse chromosome 1 (in the region syntenic to human chromosome 1q31). In addition, we identified several genes highly homologous to Ym1 that cluster at theYm1locus. We show that these genes are expressed selectively in different mouse tissues.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5593