Genetic manipulation of antitumor-agent biosynthesis to produce novel drugs

Current methods of obtaining novel drugs may be complemented in the near future by the genetic engineering of antitumor-agent biosynthesis in microorganisms. Biosynthetic gene clusters from several antitumor pathways in actinomycetes are presently being characterized and expressed in order to genera...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 1998-11, Vol.16 (11), p.475-482
Main Authors: SALAS, J. A, MENDEZ, C
Format: Article
Language:English
Subjects:
Actinomycetales - genetics
Actinomycetales - metabolism
Antineoplastic agents
Antineoplastic Agents - metabolism
Antineoplastic drugs. Cytokines
Biological and medical sciences
Biotechnology
Biotechnology - methods
Biotechnology - trends
Drug Resistance, Microbial
Fundamental and applied biological sciences. Psychology
General aspects
Genes, Bacterial
Genetic Engineering - methods
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Pharmacology. Drug treatments
Production of active biomolecules
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Summary:Current methods of obtaining novel drugs may be complemented in the near future by the genetic engineering of antitumor-agent biosynthesis in microorganisms. Biosynthetic gene clusters from several antitumor pathways in actinomycetes are presently being characterized and expressed in order to generate novel drugs. Several novel hydroxylated and glycosylated antitumor-drug derivatives have been produced that show a relaxed substrate specificity for secondary-metabolic enzymes, which opens up the possibility of generating novel drugs by genetic manipulation.
ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(98)01198-6