Three-dimensional cross-linked F-actin networks: relation between network architecture and mechanical behavior

Numerical simulations are reported for the response of three-dimensional cross-linked F-actin networks when subjected to large deformations. In addition to the physiological parameters such as actin and cross-linker concentration, the model explicitly accounts for filament properties and network arc...

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Bibliographic Details
Published in:Physical review letters 2007-11, Vol.99 (20), p.208103-208103, Article 208103
Main Authors: Huisman, E M, van Dillen, T, Onck, P R, Van der Giessen, E
Format: Article
Language:English
Subjects:
Actins - chemistry
Actins - metabolism
Biomechanical Phenomena
Biophysical Phenomena
Biophysics
Models, Chemical
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Summary:Numerical simulations are reported for the response of three-dimensional cross-linked F-actin networks when subjected to large deformations. In addition to the physiological parameters such as actin and cross-linker concentration, the model explicitly accounts for filament properties and network architecture. Complementary to two-dimensional studies, we find that the strain-stiffening characteristics depend on network architecture through the local topology around cross-links.
ISSN:0031-9007
1079-7114
DOI:10.1103/physrevlett.99.208103