Application of lipids and plasmid design for gene delivery to mammalian cells

Cationic lipids are widely used for in vitro gene transfer due to their efficiency. The major challenges for the improvement of in vivo cationic lipid-mediated gene delivery reside in the design of more biocompatible lipoplexes mimicking viral-mediated gene delivery and in understanding the fate of...

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Bibliographic Details
Published in:Current opinion in biotechnology 1998-10, Vol.9 (5), p.480-485
Main Authors: Scherman, Daniel, Bessodes, Michel, Cameron, Béatrice, Herscovici, Jean, Hofland, Hans, Pitard, Bruno, Soubrier, Fabienne, Wils, Pierre, Crouzet, Joël
Format: Article
Language:English
Subjects:
Animals
Biotechnology
Cations
Chemical Phenomena
Chemistry, Physical
Drug Design
Gene Transfer Techniques
Genetic Vectors
Humans
Lipids - chemistry
Plasmids - genetics
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Summary:Cationic lipids are widely used for in vitro gene transfer due to their efficiency. The major challenges for the improvement of in vivo cationic lipid-mediated gene delivery reside in the design of more biocompatible lipoplexes mimicking viral-mediated gene delivery and in understanding the fate of the lipoplexes within the cells.
ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(98)80033-5