Central pontine myelinolysis in AIDS

Central pontine myelinolysis (CPM) is an uncommon complication in sick patients with severe underlying disorders such as chronic alcoholism, malignancy, malnutrition and hyponatraemia. We report two patients with advanced HIV infection who developed CPM. In one case the diagnosis was not suspected i...

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Bibliographic Details
Published in:Acta neuropathologica 1998-11, Vol.96 (5), p.537-540
Main Authors: MILLER, R. F, HARRISON, M. J. G, HALL-CRAGGS, M. A, SCARAVILLI, F
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - complications
Adult
AIDS
AIDS/HIV
Alcoholism
Biological and medical sciences
Cadaver
Demyelination
Diagnosis
Drug abuse
HIV
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Magnetic Resonance Imaging
Male
Malignancy
Malnutrition
Medical sciences
Myelin
Myelinolysis, Central Pontine - diagnosis
Myelinolysis, Central Pontine - etiology
Myelinolysis, Central Pontine - pathology
Neurological complications
Pons
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Central pontine myelinolysis (CPM) is an uncommon complication in sick patients with severe underlying disorders such as chronic alcoholism, malignancy, malnutrition and hyponatraemia. We report two patients with advanced HIV infection who developed CPM. In one case the diagnosis was not suspected in life, in the other the diagnosis was made just before death, on the basis of magnetic resonance (MR) imaging appearances. At post mortem there was a close correlation between the MR abnormalities and the anatomic changes in the pons.
ISSN:0001-6322
1432-0533
DOI:10.1007/s004010050931