Effect of dimethylsulfoxide on the functions of mesenchymal and hemopoietic precursors

The effects of dimethylsulfoxide on the state of mesenchymal precursors in vivo were demonstrated. Treatment with dimethylsulfoxide reduced the content of stromal clonogenic elements in the bone marrow and inhibited mobilization of mesenchymal precursors induced by granulocyte colony-stimulating fac...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-04, Vol.143 (4), p.535-538
Main Authors: Zyuz'kov, G N, Gur'yantseva, L A, Simanina, E V, Zhdanov, V V, Dygai, A M, Goldberg, E D
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation - drug effects
Colony-Forming Units Assay
Dimethyl Sulfoxide - administration & dosage
Dimethyl Sulfoxide - pharmacology
Female
Granulocyte Colony-Stimulating Factor - metabolism
Hematopoiesis - drug effects
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - drug effects
Hematopoietic Stem Cells - metabolism
Male
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - drug effects
Mesenchymal Stem Cells - metabolism
Mice
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Summary:The effects of dimethylsulfoxide on the state of mesenchymal precursors in vivo were demonstrated. Treatment with dimethylsulfoxide reduced the content of stromal clonogenic elements in the bone marrow and inhibited mobilization of mesenchymal precursors induced by granulocyte colony-stimulating factor. In in vitro system, dimethylsulfoxide inhibited proliferation of fibroblast, erythroid, and granulomonocytic colony-forming units and stimulates maturation of hemopoietic precursors.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0173-0