Intracerebral microdialysis technique and its application on brain pharmacokinetic-pharmacodynamic study

Intracerebral microdialysis (IC-MD) has been developed as a well-validated and powerful technique for decades. As a practical sampling tool, it can gain the continuous dialysates of endogenous and exogenous substances in extracellular fluid (ECF) of awake freely moving animals. Also, variform IC-MD...

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Bibliographic Details
Published in:Archives of pharmacal research 2007-12, Vol.30 (12), p.1635-1645
Main Authors: Pan, Yue-Fang, Feng, Jian, Cheng, Qiao-Yuan, Li, Fan-Zhu
Format: Article
Language:English
Subjects:
Analgesics - pharmacokinetics
Analgesics - pharmacology
Animals
Anticonvulsants - pharmacokinetics
Anticonvulsants - pharmacology
Antidepressive Agents - pharmacokinetics
Antidepressive Agents - pharmacology
Brain - metabolism
Calibration
Microdialysis - methods
Models, Biological
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Summary:Intracerebral microdialysis (IC-MD) has been developed as a well-validated and powerful technique for decades. As a practical sampling tool, it can gain the continuous dialysates of endogenous and exogenous substances in extracellular fluid (ECF) of awake freely moving animals. Also, variform IC-MD probes (IC-MDPs) have grown more exquisite. The implantation of the IC-MDP in certain tissue of brain allows monitor drug distribution and measure drug and corresponding neurotransmitters levels in brain ECF after administration for brain pharmacokinetic-pharmacodynamic (B-PK-PD) study. So it is suitable for IC-MD to B-PK-PD study (IC-MD/B-PK-PD). The performance of IC-MD/B-PK-PD can not only elevate the degree of precision and accuracy of experimental data, minimize the individual difference by reduced number of animals, but also give important information for the prediction and optimization of drug effective dose in preclinical study. In this review, we have discussed various IC-MD/B-PK-PD studies of analgesic, antiepileptic and antidepressant drug. The role of IC-MD/B-PK-PD in confirming and assessing the drug effect before clinic trials is highlighted.
ISSN:0253-6269
1976-3786
DOI:10.1007/BF02977335