Supersensitivity to serotonin- and histamine-induced arterial contraction following ovariectomy

The modulating role of estrogens and ovariectomy on coronary artery and thoracic aortic rings was examined in female rabbits. Three treatment groups were studied: (1) control, (2) ovariectomy, and (3) ovariectomy+17β-estradiol acetate (40 μg/kg per day, i.m. for 7 days). Coronary artery reactivity w...

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Bibliographic Details
Published in:European journal of pharmacology 1998-10, Vol.359 (2-3), p.191-200
Main Authors: Ma, Lianmin, Yu, Zhou, Xiao, Suhong, Thadani, Udho, Robinson, Casey P, Patterson, Eugene
Format: Article
Language:English
Subjects:
5-HT (5-hydroxytryptamine, serotonin)
Acetylcholine - pharmacology
Adenosine - pharmacology
Animals
Aorta, Thoracic - drug effects
Aorta, Thoracic - physiology
Biological and medical sciences
Blood vessels and receptors
Coronary artery
Coronary artery spasm
Coronary Vessels - drug effects
Coronary Vessels - physiology
Dose-Response Relationship, Drug
Epinephrine - pharmacology
Estradiol - blood
Estradiol - pharmacology
Estrogen Replacement Therapy
Female
Fundamental and applied biological sciences. Psychology
Histamine
Histamine - pharmacology
Hormone metabolism and regulation
In Vitro Techniques
Mammalian female genital system
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - physiology
Nitric Oxide - metabolism
Nitroglycerin - pharmacology
Ovariectomy
Perfusion
Pinacidil - pharmacology
Potassium Chloride - pharmacology
Pressure
Rabbits
Sensitivity and Specificity
Serotonin - pharmacology
Supersensitivity
Vasoconstriction - drug effects
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
Vertebrates: cardiovascular system
Vertebrates: reproduction
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Summary:The modulating role of estrogens and ovariectomy on coronary artery and thoracic aortic rings was examined in female rabbits. Three treatment groups were studied: (1) control, (2) ovariectomy, and (3) ovariectomy+17β-estradiol acetate (40 μg/kg per day, i.m. for 7 days). Coronary artery reactivity was studied in the isolated retrogradely perfused heart. Aortic reactivity was studied using endothelium intact and denuded aortic rings. Concentration–response curves were performed to serotonin (5-HT) and histamine. A 21-fold, a 4.7-fold, and a 5.2-fold increase in sensitivity to 5-HT-induced contraction were observed in the ovariectomy group compared to the control group for coronary artery, intact aortic, and denuded aortic preparations, respectively (P
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(98)00644-X