Isolation of Translactone-containing Triterpenes with Thrombin Inhibitory Activities from the Leaves of Lantana camara

Methanolic extracts prepared from the leaves of Lantana camara have been found to inhibit human thrombin. An assay, in which thrombin activity is measured as a function of clot formation from fibrinogen, was used to guide the fractionation and purification of five principal active constituents (1−5)...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1998-11, Vol.61 (11), p.1328-1331
Main Authors: O'Neill, Melanie J, Lewis, Jane A, Noble, H. Mary, Holland, Susan, Mansat, Christine, Farthing, John E, Foster, Graham, Noble, David, Lane, Stephen J, Sidebottom, Philip J, Lynn, Sean M, Hayes, Michael V, Dix, Clive J
Format: Article
Language:English
Subjects:
antithrombin activity
Biological and medical sciences
blood coagulation factors
Carbohydrate Sequence
chemical constituents of plants
chemical structure
Crystallography, X-Ray
Fibrinogen - antagonists & inhibitors
General pharmacology
Humans
Lantana camara
leaves
Medical sciences
medicinal plants
medicinal properties
Molecular Sequence Data
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - chemistry
Plant Leaves - chemistry
Plants, Medicinal - chemistry
purification
spectral analysis
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
thrombin
Thrombin - antagonists & inhibitors
Triterpenes - isolation & purification
Triterpenes - pharmacology
triterpenoids
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Summary:Methanolic extracts prepared from the leaves of Lantana camara have been found to inhibit human thrombin. An assay, in which thrombin activity is measured as a function of clot formation from fibrinogen, was used to guide the fractionation and purification of five principal active constituents (1−5), which were all characterized as 5,5-trans-fused cyclic lactone-containing euphane triterpenes.
ISSN:0163-3864
1520-6025
DOI:10.1021/np970464j