The presence of erythropoietin receptor in parathyroid cells

Effects of erythropoietin on parathyroid cell function has not been studied before. We aimed to demonstrate whether erythropoietin receptor present in parathyroid cells. The specimens of normal parathyroid gland, parathyroid adenoma and hyperplasia were retrieved from our pathology archives. The sec...

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Published in:Journal of endocrinological investigation 2007-12, Vol.30 (11), p.RC35-RC37
Main Authors: Oztürk, M, Ustek, D, Akbas, F, Kösem, M, Abaci, N, Alagöl, F, Oztürk, G, Kotan, C
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Erythropoietin - genetics
Erythropoietin - metabolism
Gene Expression Regulation
Humans
Hyperplasia - metabolism
Hyperplasia - pathology
Parathyroid Glands - metabolism
Parathyroid Glands - pathology
Parathyroid Neoplasms - metabolism
Parathyroid Neoplasms - pathology
Receptors, Erythropoietin - genetics
Receptors, Erythropoietin - metabolism
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Summary:Effects of erythropoietin on parathyroid cell function has not been studied before. We aimed to demonstrate whether erythropoietin receptor present in parathyroid cells. The specimens of normal parathyroid gland, parathyroid adenoma and hyperplasia were retrieved from our pathology archives. The sections were stained immunohistochemically. Quantitative gene expression study was performed for erythropoietin and erythropoietin receptor. Erythropoietin receptors were detected by immunohistochemical staining and by its gene expression. Its density was higher in normal parathyroid, followed by parathyroid adenoma and hyperplasia. Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03349234