p53 is an Independent Prognostic Factor for Survival in Thyroid Cancer

Background: p53 has been reported to be of prognostic importance in different types of cancer. Immunohistochemical measurement of p53 antigen activity could be a prognostic marker for aggressiveness and survival in thyroid cancer. Different types of antibodies have been used to detect p53 in previou...

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Bibliographic Details
Published in:Anticancer research 2007-11, Vol.27 (6B), p.3993-3997
Main Authors: BACHMANN, Kai, PAWLISKA, Denise, KAIFI, Jussuf, SCHURR, Paulus, ZÖRB, Jennifer, MANN, Oliver, KAHL, Hans J, IZBICKI, Jakob R, STRATE, Tim
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Endocrinopathies
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Malignant tumors
Medical sciences
Middle Aged
Prognosis
Retrospective Studies
Staining and Labeling - methods
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
Tumor Suppressor Protein p53 - metabolism
Tumors
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Summary:Background: p53 has been reported to be of prognostic importance in different types of cancer. Immunohistochemical measurement of p53 antigen activity could be a prognostic marker for aggressiveness and survival in thyroid cancer. Different types of antibodies have been used to detect p53 in previous studies without direct comparison to each other. Patients and Methods: A series of 54 patients with thyroid cancer who had undergone thyroidectomy between 1993 and 1998 is reported. All samples were chosen retrospectively and classified by routine histopathology, followed by immunohistopathological examination with three different types of antibodies (PAb1801, CM1 and DO-7) with the peroxidase method. Survival data was generated. Results: The mean time of follow-up was 9.0 years. Eighteen patients died. Twenty-three (42.6%) samples were positive for p53 using the antibody PAb1801, 17 (31.5%) with using CM1 and only 4 (7.4%) cases with DO-7. Statistical analysis determined that the size (p=0.02) and classification of the tumor (p
ISSN:0250-7005
1791-7530