The Shaping of Pharyngeal Cartilages during Early Development of the Zebrafish

In zebrafish the cartilages of the pharynx develop during late embryogenesis and grow extensively in the larva before eventually being replaced by bone. Here we examine chondrocyte arrangements, shapes, numbers, and divisions in the young hyoid cartilages. We observe two distinct developmental phase...

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Bibliographic Details
Published in:Developmental biology 1998-11, Vol.203 (2), p.245-263
Main Authors: Kimmel, Charles B., Miller, Craig T., Kruze, Greg, Ullmann, Bonnie, BreMiller, Ruth A., Larison, Karen D., Snyder, Hannah C.
Format: Article
Language:English
Subjects:
Animals
Bromodeoxyuridine - metabolism
Cartilage - growth & development
Cell Division - physiology
Cell Size - physiology
Chondrocytes - cytology
Histocytochemistry
Hyoid Bone - growth & development
Larva - growth & development
Microscopy, Fluorescence
Morphogenesis - physiology
Mutation - genetics
Pharynx - cytology
Pharynx - growth & development
Phenotype
Zebrafish - embryology
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Summary:In zebrafish the cartilages of the pharynx develop during late embryogenesis and grow extensively in the larva before eventually being replaced by bone. Here we examine chondrocyte arrangements, shapes, numbers, and divisions in the young hyoid cartilages. We observe two distinct developmental phases, morphogenesis and growth. The first phase generates stereotypically oriented chondrocyte stacks that might form by intercalations among cells within the precartilage condensations. In mutants that have deformed cartilages the orientation of the stacks is changed, and we propose that their correct formation underlies the correct initial shaping of the organ. The following period of rapid, nearly isometric cartilage growth occurs by divisions of chondrocytes that are largely located near the joints, and appears to be under quite separate regulation.
ISSN:0012-1606
1095-564X
DOI:10.1006/dbio.1998.9016