The use angiogenesis stimulators for the treatment of chronic ischemia of lower extremities

We present the results of treatment of chronic ischemia of the lower extremities (distal form) with angiogenesis stimulators, autologous endothelioblast precursors (CD133+) and gene preparation of vascular endothelial growth factor VEGF165 (angiostimulin). Good clinical effect was attained in all pa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-07, Vol.144 (1), p.141-146
Main Authors: Bokeriya, L A, Arakaelyan, V S, Eremeeva, M V, Nisnevich, N D, Plyushch, M G, Kolesnik, D I, Demidova, O A
Format: Article
Language:English
Subjects:
AC133 Antigen
Adult
Aged
Aged, 80 and over
Angiogenesis Inducing Agents - therapeutic use
Angiography
Antigens, CD - therapeutic use
Cell- and Tissue-Based Therapy - methods
Chronic Disease
Female
Genetic Therapy - methods
Glycoproteins - therapeutic use
Humans
Ischemia - drug therapy
Leg - blood supply
Male
Middle Aged
Peptides - therapeutic use
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Summary:We present the results of treatment of chronic ischemia of the lower extremities (distal form) with angiogenesis stimulators, autologous endothelioblast precursors (CD133+) and gene preparation of vascular endothelial growth factor VEGF165 (angiostimulin). Good clinical effect was attained in all patients, which was confirmed instrumentally 1, 3, and 6 months after administration of the stimulant: transcutaneous oxygen tension on the foot, index of malleolar pressure, and walking duration increased, parameters of microcirculation improved, the number of newly formed collateral arteries increased (angiography findings), quality of life improved (SF 36 questionnaire), and parameters of coagulogram also improved. The maximum positive dynamics was observed by month 3 of the study.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0274-9