Divergent incorporation of dietary trans fatty acids in different serum lipid fractions

Trans fatty acids may be involved in atherosclerotic vascular diseases. We investigated the incorporation of dietary trans fatty acids and oleic acid into the serum triglycerides (TG), cholesterol esters (CE), and phospholipids (PL). Fourteen healthy female volunteers, aged 23.2±3.1 yr (mean±SD), bo...

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Bibliographic Details
Published in:Lipids 1998-10, Vol.33 (10), p.955-962
Main Authors: Vidgren, H.M, Louheranta, A.M, Agren, J.J, Schwab, U.S, Uusitupa, M.I.J
Format: Article
Language:English
Subjects:
Adult
Body Weight - drug effects
Cholesterol
Cholesterol Esters - blood
Cholesterol Esters - chemistry
Cholesterol Esters - metabolism
Cross-Over Studies
Diet
diet-related diseases
Dietary Fats, Unsaturated - pharmacology
Esters
Fatty acids
Fatty Acids - analysis
Fatty Acids - blood
Fatty Acids, Unsaturated - pharmacology
Female
human nutrition
Humans
Lipid Metabolism
Lipids
Lipids - blood
Lipids - chemistry
Metabolites
Myristic Acid - analysis
Myristic Acid - chemistry
Nutrition
nutrition physiology
Oleic Acid - pharmacology
Polyunsaturated fatty acids
Trans fats
Triglycerides - blood
Triglycerides - chemistry
Triglycerides - metabolism
Vascular diseases
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Summary:Trans fatty acids may be involved in atherosclerotic vascular diseases. We investigated the incorporation of dietary trans fatty acids and oleic acid into the serum triglycerides (TG), cholesterol esters (CE), and phospholipids (PL). Fourteen healthy female volunteers, aged 23.2±3.1 yr (mean±SD), body mass index 20.8±2.1 kg/m2 participated in this study. All subjects consumed both a trans fatty acid‐enriched diet (TRANS diet) and an oleic acid‐enriched diet (OLEIC diet) for 4 wk according to a randomized crossover design. Both experimental diet periods were preceded by consumption of a baseline diet for 2 wk which supplied 37% of total energy (E%) as fat: 18 E% from saturated fatty acids (SFA), 12 E% from monounsaturated fatty acids, and 6 E% from polyunsaturated fatty acids. Five E% of the SFA in the baseline diet was replaced by trans fatty acids (18∶1 t and 18∶2 c,t+18∶2t,t, where c is cis and t is trans) in the TRANS diet and by oleic acid (18∶1n‐9) in the OLEIC diet. After the TRANS diet, the proportions of 18∶1t and 18∶2t increased (P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-998-0292-9