Evaluation of activity, chronicity and tubulointerstitial indices for childhood lupus nephritis

Few data exist on use of the National Institutes of Health (NIH) activity index (AI) and chronicity index (CI) in childhood lupus nephritis (LN). A tubulointerstitial activity index (TIAI) has been derived but not validated. We evaluated clinicopathologic correlations of the AI, CI and TIAI in child...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2008, Vol.23 (1), p.83-91
Main Authors: Zappitelli, Michael, Duffy, Ciarán M., Bernard, Chantal, Gupta, Indra R.
Format: Article
Language:English
Subjects:
Adolescent
Biopsy
Child
Chronic Disease
Classification
Creatinine
Female
Humans
Kidney - pathology
Kidney diseases
Lupus
Lupus Nephritis - pathology
Male
Medicine & Public Health
Nephrology
Original Article
Pediatrics
Retrospective Studies
Rheumatology
Urology
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Summary:Few data exist on use of the National Institutes of Health (NIH) activity index (AI) and chronicity index (CI) in childhood lupus nephritis (LN). A tubulointerstitial activity index (TIAI) has been derived but not validated. We evaluated clinicopathologic correlations of the AI, CI and TIAI in children with LN who had undergone initial renal biopsy ( n  = 25, age 12.4 ± 2.7 years, biopsy 1) and 1 year after treatment ( n  = 15, biopsy 2). The TIAI correlated with the AI at biopsy 1 (r = 0.76, P  = 0.001) and biopsy 2 (r = 0.52, P  = 0.05), but not with CI scores. Mean AI and CI scores changed substantially from biopsy 1 to biopsy 2 ( P  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-007-0619-7