Preparation and properties of radioactive rhenium glass microspheres intended for in vivo radioembolization therapy

Rhenium glass microspheres composed of metallic rhenium particles dispersed within a magnesium alumino borate glass matrix were produced by sintering ReO2 powder and glass frit at 1050°C. The in vitro chemical durability of radioactive and nonradioactive microspheres was determined from chemical cor...

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Bibliographic Details
Published in:Journal of biomedical materials research 1998-12, Vol.42 (4), p.617-625
Main Authors: Conzone, Samuel D., Häfeli, Urs O., Day, Delbert E., Ehrhardt, Gary J.
Format: Article
Language:English
Subjects:
Biocompatible Materials
Biological and medical sciences
Body Fluids
Brachytherapy - methods
Diseases
Dosimetry
Embolization, Therapeutic - methods
Glass
glass microspheres
Humans
Liver Neoplasms - radiotherapy
liver tumor treatment
Medical applications
Medical sciences
Microspheres
Neutron activation analysis
Radiation therapy and radiosensitizing agent
Radioisotopes
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - therapeutic use
Radiotherapy
Radiotherapy Dosage
Re-186
Re-188
Rhenium
rhenium radioisotopes
Treatment with physical agents
Treatment. General aspects
Tumors
Yttrium Radioisotopes
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Summary:Rhenium glass microspheres composed of metallic rhenium particles dispersed within a magnesium alumino borate glass matrix were produced by sintering ReO2 powder and glass frit at 1050°C. The in vitro chemical durability of radioactive and nonradioactive microspheres was determined from chemical corrosion tests on microspheres immersed in phosphate‐buffered saline (PBS) solution at 37°C. The dosimetric properties of these microspheres also were calculated. The rhenium glass microspheres are chemically durable in body fluids and release < 1.2% of radioactive rhenium after being immersed in PBS solution for 32 days at 37°C. Therapeutic radioactive rhenium activities can be obtained in < 10 h by neutron activation of these microspheres in a thermal neutron flux of 8 × 1013 cm−2s−1. A 50 mg injection of radioactive rhenium glass microspheres containing 3.7 GBq of 186Re and 8.5 GBq of 188Re could deliver a 100 Gy dose to a cancerous liver while limiting the total body dose from rhenium dissolution in vivo to approximately 1 mGy. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 42, 617–625, 1998.
ISSN:0021-9304
1097-4636
DOI:10.1002/(SICI)1097-4636(19981215)42:4<617::AID-JBM19>3.0.CO;2-4