YM90K, an AMPA receptor antagonist, protects against ischemic damage caused by permanent and transient middle cerebral artery occlusion in rats

The neuroprotective effect of YM90K, a potent AMPA receptor antagonist, was examined in rats with permanent and transient occlusion of middle cerebral artery (MCA) using intraluminal suture occlusion method. In rats with permanent MCA occlusions, two types of occluders were used to compare the effic...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1998-11, Vol.358 (5), p.586-591
Main Authors: Kawasaki-Yatsugi, S, Ichiki, C, Yatsugi, S, Shimizu-Sasamata, M, Yamaguchi, T
Format: Article
Language:English
Subjects:
Animals
Arterial Occlusive Diseases - pathology
Arterial Occlusive Diseases - physiopathology
Brain - blood supply
Brain - drug effects
Brain - pathology
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Brain Ischemia - prevention & control
Cerebral Arteries
Cerebral Infarction - pathology
Cerebral Infarction - prevention & control
Male
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Quinoxalines - pharmacology
Quinoxalines - therapeutic use
Rats
Rats, Sprague-Dawley
Receptors, AMPA - antagonists & inhibitors
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Summary:The neuroprotective effect of YM90K, a potent AMPA receptor antagonist, was examined in rats with permanent and transient occlusion of middle cerebral artery (MCA) using intraluminal suture occlusion method. In rats with permanent MCA occlusions, two types of occluders were used to compare the efficacy of YM90K. When a 4-0 (diameter: 0.19 mm) suture was used, YM90K (20 mg kg(-1) h(-1) i.v. infusion for 4 h) significantly reduced infarct volume (P
ISSN:0028-1298
DOI:10.1007/pl00005297